关键词: 舌鳞癌, 多药耐药, P-糖蛋白, 多药耐药相关蛋白, 谷胱苷肽-S转移酶

Abstract:

Objective　To explore the correlation of chemotherapy efficacy in tongue squamous cell carcinoma(SCC) with ex- pression level of P-glycoprotein(Pgp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathiones-tranferase (GST-π), DNAtopo-isomeraseⅡα(TopoⅡα).Methods　The expression patterns of Pgp, MRP, LRP, GST-πand TopoⅡαin 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohisto- chemically labelled streptavidin bioein method (LsAB).Results　The expression ratios of Pgp, MRP, LRP, GST-πand TopoⅡ αin pre-chemotherapy cases were 47·5%, 50%, 35%, 45%, 82·5%, respectively. No relations between expression of Pgp, MRP, LRP, GST-π, TopoⅡαand clinic indexes were established (P>0·05). Expression ratios of Pgp, MRP in post-chemo- therapy cases were higher than that in pre-chemotherapy cases (P<0·05). Expression of Pgp and MRP showed relevance with drug resistance (P<0·05). The co-expressionwas common, the ratios of co-expression of Pgp, MRP, GST-πandMRP, GST-π in chemotherapy non-responders were 40% and 50%, respectively, but 0 in responders.Conclusion　The intrinsic multidrug resistance of tongue SCC is relevant to the effects of Pgp, MRP, GST-π.

Key words: tongue sequamous cell carcinoma, multidrug resistance, P-glycoprotein, multidrug resistance-associated protein, glutathione-S-tranferase