关键词: 化疗, 口腔鳞癌, 多药耐药性

Abstract:

Objective　To study and evaluate the clinical effects of combined preoperative chemotherapy and their rela- tionswith multi drug resistance (MDR).Methods　102 cases with oral squamous cell carcinoma(OSCC) were included in the study (63 males and 39 females,aged 22 to 67 years). Amongthe subjects therewere 57 caseswith cancer of tongue and 45 cases with cancer of buccal mucosa.27 cases in the groupwere classified as stageⅡ,55 as stageⅢand 20 cases as stageⅣaccording to TNMstandard.All cases accepted PYM+5-Fu+DDP combined chemotherapy pre-operatively.The total given dosewas PYM48 mg,5-Fu 7·5 g and DDP300 mg.Afterthe chemotherapy,radical surgerywere performedwithin 2 weeks.The diagnosis of all cases were proved as OSCC by biopsy.Results　Total effective rate of the combined chemotherapy was 82·4%. All of the cases were followed up and their 3 years′survival rate was 67·6%.Conclusion　The combined chemotherapy of PYM+5-Fu+DDP is ef- fective in using as one of comprehensive treatment for OSCC.

Key words: chemotherapy, oral squamous cell carcinoma, multi drug resistance