华西口腔医学杂志

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聚羟基丁酸酯膜覆盖拔牙创的实验研究

田卫东,包崇云,刘磊,李声伟,汤炜   

  1. 610041 四川大学华西口腔医学院
  • 收稿日期:2002-08-25 修回日期:2002-08-25 出版日期:2002-08-20 发布日期:2002-08-20
  • 基金资助:
    本课题为四川省科委重点资助项目

An Experimental Study of Covering the Tooth Sockets with Polyhydroxybutyrate Membrane in Animals

Tian Weidong, Bao Chongyun, Liu Lei, et al   

  1. West China College ofStomatology, Sichuan University
  • Received:2002-08-25 Revised:2002-08-25 Online:2002-08-20 Published:2002-08-20

摘要:

目的:探讨采用改性和单聚聚羟基丁酸酯膜(PHBm)引导拔牙窝骨修复和改建的效果。方法:拔除4只家犬双上下颌骨两颗前磨牙,分别采用改性PHBm覆盖、单聚PHBm覆盖及无膜空白对照处理。通过大体观察、X线片、组织病理学、四环素荧光显微观察和同位素骨扫描检查牙槽嵴情况。结果:与无膜空白对照相比,改性和单聚 PHBm组修复、重建速度加快,较好地保持了牙槽嵴的外形和高度。结论:拔牙后应用改性PHBm和单聚PHBm覆盖拔牙创,能保护拔牙创内的血凝块,加速骨再生过程,可保持牙槽嵴良好外形及高度。

关键词: 引导组织再生, 聚羟基丁酸酯, 牙槽嵴, 骨再生

Abstract:

Objective:The aim of this study was to investigate the effect of modified polyhydroxybutyrate membranes and polyhydroxybu- tyrate membranes (PHBm) on guided bone regeneration of fresh extract tooth sockets.Methods:The extract tooth socketswere es- tablished by extracted two premolars in each quadrant of a dog. The tooth sockets were covered with the modified PHBm, PHBm and without covering. The dogswere sacrificed in 1,2,3,6 months after surgery. Visual observation, radiography, SPECT, histo- logical inspection and tetracycline measurementwere carried out to evaluate the effects of these twomaterials on preserving alveolar ridge.Results:The results indicated that modified PHBm and PHBm improved the restoration of the socket and preserved the con- tour and height of the alveolar ridges.Conclusion:Modified PHBm and PHBm can be used in protecting extract tooth sockets and preserve alveolar ridges.

Key words: guided tissue regeneration, polyhydroxybutyrat emembrane, alveolar ridge