弱激光对正畸牙移动中牙周组织碱性成纤维细胞生长因子表达的影响

华西口腔医学杂志

弱激光对正畸牙移动中牙周组织碱性成纤维细胞生长因子表达的影响

朱宪春,陈远萍,孙新华

130041 吉林大学口腔医学院

收稿日期:2002-06-25 修回日期:2002-06-25 出版日期:2002-06-20 发布日期:2002-06-20
基金资助:
本课题为吉林省科委资助项目(编号970322)

A Study on Expression of Basic Fibroblast Growth Factors in Periodontal Tissue Following Orthodontic Tooth Movement Associated with Low Power Laser Irradiation

Zhu Xianchun, Chen Yuanping, Sun Xinhua

Department ofOrthodontics,School forStomatology,Jilin University

Received:2002-06-25 Revised:2002-06-25 Online:2002-06-20 Published:2002-06-20

摘要/Abstract

摘要：

目的:探讨弱激光照射对兔实验性牙齿移动过程中牙周组织碱性成纤维细胞生长因子(bFGF)表达的影响。方法:18只大耳白兔按每组3只随机分为实验1、3、5、7、14、21 d组。2%戊巴比妥钠麻醉下于双侧上颌第一磨牙与切牙间拴结不锈钢螺簧,施力80 g。左侧为对照侧,右侧为实验侧,进行弱激光照射。通过免疫组织化学染色进行 bFGF半定量分析。结果:经弱激光照射后,照射侧牙周组织中bFGF表达高于对照侧,照射侧张力区、压力区牙周膜中bFGF表达在5、7、14 d时较对照侧有显著性差异;照射侧张力区牙槽骨表面成骨区bFGF的表达在14 d时显著高于对照侧。结论:弱激光照射促进了牙周组织中bFGF的表达,促进了牙周组织的改建。

关键词: 弱激光, 牙齿移动, 碱性成纤维细胞生长因子, 免疫组织化学

Abstract:

Objective:The purpose of this study was to investigate the effects of low power laser on basic fibroblast growth factors (bFGF) expression in periodontal tissue during tooth movement.Methods:18 white rabbits were randomly divided into 6 groups with 3 rabbits in each group, including groups of l, 3, 5, 7, 14 and 21days. Under an anesthesia condition by 2% pentobarbital sodium, the stainless coil springswere fixed between the firstmaxillary molar and the incisorproducing the force of 80 g. The right side of maxilla was considered as the experimental group under the irradiation of low power laser with the left side as the control groups. The expression of bFGF was investigated half-quantitatively through immunohistochemical analysis.Results:The expres- sion of bFGF in periodontal tissue with irradiation of lowpower laserwas higherthan the control side. There were significantdiffer- ences among the 5, 7, and 14 day groups. In the tension area of the experimental side, the expression of bFGF in the osteoblastic surface of alveolarbone was characteristically greaterthan thatof the control side.Conclusion:The laserof lowpowerpromotes the expression of bFGF in the periodontal tissue and alveolar bone remodeling.

Key words: lowpowerlaser\\toothmovement\\basicfibroblastgrowthfactor\\immunohistochemistry

朱宪春,陈远萍,孙新华. 弱激光对正畸牙移动中牙周组织碱性成纤维细胞生长因子表达的影响[J]. 华西口腔医学杂志.

Zhu Xianchun, Chen Yuanping, Sun Xinhua. A Study on Expression of Basic Fibroblast Growth Factors in Periodontal Tissue Following Orthodontic Tooth Movement Associated with Low Power Laser Irradiation[J]. West China Journal of Stomatology.

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