聚羟基丁酸酯作为引导组织再生膜材料的初探

华西口腔医学杂志

聚羟基丁酸酯作为引导组织再生膜材料的初探

包崇云,陈治清,欧国敏,邱静,何开泽,赵树杰

610041 四川大学华西口腔医学院(包崇云,陈治清,欧国敏,邱静),中国科学院成都生物所(何开泽,赵树杰)

收稿日期:2002-04-25 修回日期:2002-04-25 出版日期:2002-04-20 发布日期:2002-04-20

A Preliminary Study on Polyhydroxybutyrate Membrane for Guided Tissue Regeneration

Bao Chongyun, Chen Zhiqing, Ou Guomin, et al

Bao Chongyun, Chen Zhiqing, Ou Guomin, et al College of Stomatology,West China University of MedicalSciences He Kaize, Zhao Shujie Chengdu Institute of Biology,Chinese AcademyofSciences

Received:2002-04-25 Revised:2002-04-25 Online:2002-04-20 Published:2002-04-20

摘要/Abstract

摘要：

目的:研制一种有一定机械强度又可体内降解的引导组织再生膜,探索聚羟基丁酸酯作为引导组织再生膜的可行性。方法:采用溶剂挥发法制备PHB膜,将膜植入动物体内,分别于1周,1、2、3月取PHB膜及周围组织考察体内降解性,评价组织相容性。结果:溶剂挥发法制备PHB膜具备足够的机械强度,可在体内缓慢降解,具有良好组织相容性。结论:PHB膜能满足作为引导组织再生膜的基本要求,有可能成为一种较理想的引导组织再生的天然膜材料。

关键词: 聚羟基丁酸酯, 引导组织再生膜, 生物降解, 生物相容性

Abstract:

Objective:An ideal guided tissue regeneration membrane (GTRm) should possesses good biocompatibility, adequate me- chanical strength and biodegradability. Polyhydroxybutyrate(PHB) is a biodegradable hermopolymer that composed by microorgan- isms. The objective of this study was to explore the possibility of using PHB membrane for guided tissue regeneration.Methods: PHB membrane was prepared by solvent-casting techniques and its physical and chemical properties were examined. Biodegrad- ability and biocompatibility of PHB membranes were inspected by embedding PHB membranes into dogs for 1 week, 1, 2, and 3 months. The scanning electronmicroscopy (SEM) was used to evaluated biodegradability of PHB membranes, and biocompatibility of PHB membranes was tested by detecting local tissue response with light microscopy (LM).Results: (1)The extension strength and the elongation of fracture of PHB membraneswere 2812 MPa and 113% respectively. (2)The morphologic observation of PHB membranes at different terms showed that the surface turned rough because PHB membranes had been biodegraded gradually. (3) The capsule surrounding PHB membrane wasmainly consisted of fibrocytes and few lymphocytes. The longerwe observed, the thi- nner the capsule enveloping PHB membrane formed.Conclusion: PHB membranes possess satisfactory mechanical properties, bio- compatibility and, can be biodegraded slowly in vivo. PHB membranes could be therefore applied as a biological material for GTR.

Key words: polyhydroxybutyrate（PHB）, guided tissue regeneration membrane（GTRm）, biodegradation, biocompatibility

包崇云,陈治清,欧国敏,邱静,何开泽,赵树杰. 聚羟基丁酸酯作为引导组织再生膜材料的初探[J]. 华西口腔医学杂志.

Bao Chongyun, Chen Zhiqing, Ou Guomin, et al. A Preliminary Study on Polyhydroxybutyrate Membrane for Guided Tissue Regeneration[J]. West China Journal of Stomatology.

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