华西口腔医学杂志

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海绵状血管瘤硬化治疗药物对兔耳静脉硬化作用比较的实验研究

郭军, 吴汉江   

  1. 410011 湖南医科大学附二院口腔科(郭 军现在东南大学医学院附属扬州医院口腔科)
  • 收稿日期:2001-08-25 修回日期:2001-08-25 出版日期:2001-08-20 发布日期:2001-08-20
  • 基金资助:

    本课题为卫生部科学研究基金资助项目(编号94-2-084)

An Experimental Study on the Blood Vessel Sclerosing Therapeutic Agents for Cavernous Hemagiomas

Guo Jun, Wu Hanjiang   

  1. The Department of Stomatology, The Second Affiliated Hospital, Hunan Medical University
  • Received:2001-08-25 Revised:2001-08-25 Online:2001-08-20 Published:2001-08-20

摘要:

目的:筛选硬化治疗药物,探讨硬化治疗海绵状血管瘤的机制。方法:以兔耳缘静脉为实验模型,将84只兔耳随机分成6组,即注射生理盐水组、5%鱼肝油酸钠组、10%明矾组、平阳霉素加地塞米松组、平阳霉素组、长春新碱组,分别于注药后3、7、14、21、28、35 d对兔耳缘静脉进行大体、光镜和透射电镜观察。结果:¹鱼肝油酸钠注射易致组织坏死,不宜大剂量使用,在口咽部等重要血管密集区域及美容要求较高的面部皮肤处使用应慎重。10%明矾作用效果稳定,且组织反应较鱼肝油酸钠轻。固醇类激素与平阳霉素产生协同作用,且组织反应轻。º能造成内皮细胞严重损伤的药物都可能对海绵状血管瘤具有一定治疗作用。结论:固醇类激素与平阳霉素两种药物联合使用,可能对海绵状血管瘤具有较好的治疗作用。

关键词: 硬化治疗药物, 实验模型, 海绵状血管瘤

Abstract:

Objective:This study was designed to testwhat are the suitable drugs for sclerotherapy and investigate the formation mecha- nism of cavernous hemagiomas.Methods:A total of 84 rabbits were selected for this study, and divided into 6 groups, including one control group and five experimental groups. We selected auricular veins of rabbits as the location of injection. The rabbits of the control were injected with physiological saline, and the rabbits of the experimental groupswere injected respectively with vari- ous drugs, including 5% sodium morrhuate, 10% alum, pinyungmycin, leurocristine and the combination of pinyungmycin and dexamethasone. Histopathological changeswere analyzed after3, 7, 14, 21, 28, 35 days of sclerotherapy.Results:According to histopathological changes of tissue, 5% sodium morrhuate, 10% alum, and the combination of pinyungmycin and dexamethasone produced bettereutherapeutic effects, when comparingwith othermethods. However, 5% sodiummorrhuate caused tissue necrosis of the injection site.Conclusion:The combined therapy of pinyungmycin and dexamethasone produced excellent scleritic effects. Whatever drugs causing serious damage of HVEC may contribute to the therapy for cavernous hemagiomas.

Key words: sclerosing agent, experimental model, cavernous hemagioma