West China Journal of Stomatology

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Expression and Significance of Cyclin D1 in Human Adenoid Cystic Carcinoma

HE Wei1,HE Wei2,CAO Xuan-ping3,LI Long-jiang1   

  1. 1.Key.Laboratory of Oral Biomedical Engineering Ministry ofEducation,Sichuan University,Chengdu610041, China; 2.Dept.ofOral and Maxillofacial Surgery,The First AffiliatedHospital ofZhengzhou University,Zhengzhou450052, China; 3.Dept.of Oral and Maxillofacial Surgery,The College ofStomatology,Zhengzhou University,Zhengzhou450052, China
  • Received:2005-06-25 Revised:2005-06-25 Online:2005-06-20 Published:2005-06-20

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Abstract:

Objective　To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clini- cal characters.Methods　The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue.Results　The expression of cyclin D1 in normal tissue was negative, significantly different from PA and ACC (P<0·05). The expression level of PA was signifi- cantly lower than ACC (P<0·05). High expression of cyclin D1 was correlated with clinical stage and histological classification (P<0·05), but notwith sex, age, tumor site, recurrence, metastasis.Conclusion　High expression of cyclin D1 promotes the formation and development of ACC.

Key words: adenoid cystic carcinoma, pleomorphic adenoma, cyclin D1, immunohistochemistry

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