West China Journal of Stomatology

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An Experimental Study on PLGA Carrier for Oral Tissue Engineered Mucosa by Subcutaneous Implantation in Rabbits

QI Bing1，Ll Hong-weiz2，WEN Yw nting3，WANG Chang-mei3，LI Long-jiang3，SONG Xiao-ling1   

  1. 1.Dept.of Oral Pathol- 0g)，Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China;2. Dept.of Oral and Maxillofacial Sur- gery, Stornatological Hospital of Nanjing Medical Uni_rsity, Nanjing 210029, China;3. Dept.of Oral and Maxillofacial Sur- gery, West China College of Stomatology，Sichuan University, Chengdu 610041，China
  • Received:2004-10-25 Revised:2004-10-25 Online:2004-10-20 Published:2004-10-20

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Abstract:

Objective To look for the best carrier for cultivating oral tissue engineered mucosa. Methods A series of mem- brane of scaffold materials of polycleelide-co-plycoclide (PLGA)were studied on their weight and biocompatibilityafter they had been implanted subcutaneously in rabbits for 1, 2 , 3 , 4 weeks respectively. Results PLGAI，II，III degraded completely in rab- bits after 2,3,4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGAI，II，III with surrounding tissues were normal and membranes had a good biocompatibility. Conclusion The biode- grading rate of PLGA II is suitable for clinic practice. PLGA II~a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate..

Key words: polyclechde-co-plycochde, biomaterials, biocompatibility

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