West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (2): 198-204.doi: 10.7518/hxkq.2020.02.015

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Development of precancerous lesions of oral mucous membrane diseases and oral cancer animal models

Cheng Junxin, Bai Hetian, Chang Zhinan, Li Jing(), Chen Qianming   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-12 Revised:2020-01-07 Online:2020-04-01 Published:2020-04-15
  • Contact: Jing Li E-mail:lijing1984@scu.edu.cn
  • Supported by:
    National Key Research and Development Plan of China(2017YFC0840100);National Key Research and Development Plan of China(2017YFC0840107);The National Natural Science Foundation of China(81872211);The National Natural Science Foundation of China(81672675);The National Natural Science Foundation of China(81621062);Overseas Expertise Introduction Project for Discipline Innovation(111) Project(B14038);Creative Innovation Experiment Project of College Students of Sichuan University(20171082);Creative Innovation Experiment Project of College Students of Sichuan University(20171083)

Abstract:

Precancerous lesions of oral mucous membrane diseases and oral cancer are common diseases in developing countries, especially in South Asia. However, the cancerous mechanism remains unclear, and no efficient treatment and prognosis measure are currently available. Thus, precancerous lesions of the oral mucosa and oral cancer animal models must be identified to further understand their function. In this paper, we systematically review the development of oral mucosal precancerous lesions and oral cancer animal models by referring to related research.

Key words: precancerous lesions of oral mucous membrane disease, oral cancer, animal model

CLC Number: