West China Journal of Stomatology ›› 2015, Vol. 33 ›› Issue (6): 570-574.doi: 10.7518/hxkq.2015.06.004

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Establishment of a miniature pig model of mandibular osteoradionecrosis

Li Song1, Fang Dianji2, Wang Zhanyi1, Zhai Lulu3, Ning Zhaorong4, Guo Yanwei4   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Changchun Hospital of Stomatology, Changchun 130000, China; 2. Dept. of Oral and Maxillofacial Surgery, Minhang Distric Dental Hospital, Shanghai 200011, China; 3. College of Plant Science, Jilin University, Changchun 130062, China; 4. Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Second Affiliated Hospital, Jiamusi University, Jiamusi 154000, China)
  • Received:2015-04-10 Revised:2015-08-10 Online:2015-12-01 Published:2015-12-01

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Abstract: Objective To establish a miniature pig model of mandibular osteoradionecrosis (ORN). Methods A single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination. Results At 3–4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group. Conclusion A miniature pig model of mandibular ORN can be established through 25 Gy irradiation+dental extraction.

Key words: osteoradionecrosis, mandible, miniature pig, animal model

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