程序性死亡受体-1及其配体在口腔鳞状细胞癌中的研究进展

doi:10.7518/hxkq.2020.04.017

摘要/Abstract

摘要：

口腔鳞状细胞癌（OSCC）是一种常见的口腔颌面部恶性肿瘤,目前对于OSCC的治疗主要是以手术为主的综合序列治疗,但5年生存率仍不高。因此,对OSCC发病机制及治疗的研究就显得极其重要。免疫检查点程序性死亡受体-1（PD-1）和程序性死亡受体-1配体（PD-L1）是近年来的研究热点,大量研究表明PD-1/PD-L1在多数OSCC微环境中高表达,有助于实现肿瘤的免疫逃逸。本文对PD-1/ PD-L1及其抑制剂在OSCC中的研究现状进行综述。

关键词: 程序性死亡受体-1, 程序性死亡受体-1配体, 口腔鳞状细胞癌

Abstract:

Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the oral and maxillofacial region. At present, the treatment of OSCC is mainly based on surgical oriented comprehensive sequence therapy, especially the triple therapy of surgery, radiotherapy, and chemotherapy. However, the overall five-year survival rate is relatively low. Therefore, researching the pathogenesis and treatment methods of OSCC is important. The immune checkpoint of programmed death receptor-1 (PD-1) and programmed death receptor-1 ligand (PD-L1) have been the focus of research in recent years. Several studies have shown that the high expression of PD-1/PD-L1 in most OSCC microenvironments may contribute to the immune escape of tumors. In this study, the research status of immune checkpoint of PD-1/PD-L1 and its relevant inhibitors in OSCC were reviewed.

Key words: programmed death receptor-1, programmed death receptor-1 ligand, oral squamous cell carcinoma

中图分类号:

R739.8

陈志红, 吴亚东. 程序性死亡受体-1及其配体在口腔鳞状细胞癌中的研究进展[J]. 华西口腔医学杂志, 2020, 38(4): 449-453.

Chen Zhihong, Wu Yadong. Development of programmed death receptor-1 and programmed death receptor-1 ligand in oral squamous cell carcinoma[J]. West China Journal of Stomatology, 2020, 38(4): 449-453.

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