人体微生物组在辅助2型糖尿病诊疗中的潜在应用

doi:10.7518/hxkq.2019.05.020

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (5): 556-562.doi: 10.7518/hxkq.2019.05.020

人体微生物组在辅助2型糖尿病诊疗中的潜在应用

刘云坤,徐欣,周学东()

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科,成都 610041

收稿日期:2019-04-15 修回日期:2019-07-09 出版日期:2019-10-01 发布日期:2019-10-15
通讯作者: 周学东 E-mail:zhouxd@scu.edu.cn
作者简介:刘云坤,硕士,E-mail：121438062@qq.com
基金资助:
国家自然科学基金(81430011);国家自然科学基金(81670978);四川省科技厅重大前沿项目(2016JY0006)

Potential application of human microbiomes in the diagnosis and treatment of type 2 diabetes mellitus

Liu Yunkun,Xu Xin,Zhou Xuedong()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2019-04-15 Revised:2019-07-09 Online:2019-10-01 Published:2019-10-15
Contact: Xuedong Zhou E-mail:zhouxd@scu.edu.cn
Supported by:
The National Natural Science Foundation of China(81430011);The National Natural Science Foundation of China(81670978);The Key Project for Frontier Research of Science and Technology Department of Sichuan Province(2016JY0006)

摘要/Abstract

摘要：

人体微生物组是指人体体表及内部的微生物的遗传信息总和,与人类健康与疾病状态存在密切关系。口腔和肠道微生物是最具多样化的微生物群落,两者可以交互影响,在疾病发生发展过程中共同发挥作用,并可以实时反映机体的健康与疾病状态。2型糖尿病是由遗传和环境因素引起的代谢紊乱,最近的研究指出微生物与糖尿病存在关联。本文结合近期的研究进展,就2型糖尿病患者口腔微生物和肠道微生物的特征进行综述,有望为探索基于微生物组特征的2型糖尿病风险预测、诊断和预后预测的疾病模型的建立提供参考依据。

关键词: 2型糖尿病, 口腔微生物组, 肠道微生物组, 精准医疗

Abstract:

Human microbiome refers to the total microorganism genetic information of human body surface and internal, which is closely related to human health and disease. Oral and gut microbiomes are the most diverse microbial communities, which can interact and play a role in the development of the disease, and can reflect the health and disease state in real time. Type 2 diabetes mellitus is a metabolic disorder caused by both genetic and environmental factors. Recent research has shown a link between microbes and diabetes. This article reviewed the latest research on the changes of oral and gut microbiomes in type 2 diabetes mellitus patients, which expects to provide a reference for exploring the development of the disease model for prediction, diagnosis and prognosis of type 2 diabetes mellitus based on human microbiome characteristics.

Key words: type 2 diabetes mellitus, oral microbiome, gut microbiome, precision medicine

中图分类号:

刘云坤,徐欣,周学东. 人体微生物组在辅助2型糖尿病诊疗中的潜在应用[J]. 华西口腔医学杂志, 2019, 37(5): 556-562.

Liu Yunkun,Xu Xin,Zhou Xuedong. Potential application of human microbiomes in the diagnosis and treatment of type 2 diabetes mellitus[J]. West China Journal of Stomatology, 2019, 37(5): 556-562.

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人体微生物组在辅助2型糖尿病诊疗中的潜在应用

Potential application of human microbiomes in the diagnosis and treatment of type 2 diabetes mellitus

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