Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis

doi:10.7518/hxkq.2021.02.011

Abstract

Abstract: Objective

This study was performed to review the efficacy of curcumin in the treatment of oral submucous fibrosis systematically.

Methods

We searched seven databases, including Web of Science, PubMed, EBSCO, The Cochrane Library, CNKI, WanFang Data, and VIP, to obtain randomized controlled trials related to the treatment of oral submucous fibrosis by curcumin. Each database was searched from inception to 30 June 2019. RevMan 5.3 software was used for the meta-analysis.

Results

Six randomized controlled trials involving 350 patients were included in this study. Meta-analysis showed that curcumin can increase the maximal mouth opening and improve burning sensation compared with placebo treatment. Curcumin was not as effective as the controls in achieving maximal mouth opening after 1 month of treatment. However, no statistically significant difference was observed between the treatments from 2 months to 6 months. Curcumin significantly improved burning sensation compared with the controls after 3 months of treatment. No statistically significant diffe-rence in burning sensation was observed between the curcumin and control groups after 1, 2, and 6 months of treatment.

Conclusion

The current evidence shows that curcumin is an effective treatment for improving maximal mouth opening and burning sensation in patients with oral submucous fibrosis. Given the limited number and low quality of the included studies, however, more high-quality studies are needed to verify these findings.

Key words: oral submucous fibrosis, curcumin, Meta-analysis, evidence-based medicine

CLC Number:

R 781.5

Guo Jincai, Xie Hui, Wu Hao, Tong Tiejun. Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis[J]. West China Journal of Stomatology, 2021, 39(2): 195-202.

Figures/Tables 8

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步骤	检索策略
1	“Oral submucous fibrosis”[MeSH] OR “OSF” [MeSH] OR “OSMF” [MeSH]
2	“Atrophia idiopathica mucosae oris” [Title/Abstract] OR “Diffuse oral submucous fibrosis” [Title/Abstract] OR “Submucous fibrosis of the palate and pillars” OR “Idiopathic scleroderma of the mouth” [Title/Abstract] OR “Asian side-ropenic dysphagia” [Title/Abstract] OR “Sclerosing stomatitis” [Title/Abstract] OR “Idiopathic palatal fibrosis” [Title/Abstract] OR “Juxta-epithelial fibrosis” [Title/Abstract]
3	1 OR 2
4	“Curcumin” [Title/Abstract] OR “Turmeric” [Title/Abstract]
5	3 AND 4

纳入研究	例数 (T/C)	年龄/岁		性别（男/女）		干预措施		疗程/月	随访时间/月	结局指标
纳入研究	例数 (T/C)	年龄/岁		性别（男/女）		T	C	疗程/月	随访时间/月	结局指标
Piyush 等^[16]	30/30	17~60（32）		53/7		姜黄素300 mg, po,bid	番茄红素8 mg,po, bid	6	3	①② ③④
Saran 等^[17]	30/30	T:27.9±8.66	C:26.00±6.43	T:21/9	C:19/11	姜黄素300 mg, po,tid	番茄红素4 mg,po, bid	3	1	①②
Ara 等^[18]	50/50	T:25.42±7.38	C:25.44±5.43	T:45/5	C:48/2	姜黄素500 mg, po,bid	安慰剂500 mg,po, bid	6	0	①② ③④
Kopuri 等^[19]	15/15	不详		不详		姜黄素400 mg, po,bid	番茄红素4mg,po, bid	3	0	①② ⑤⑥
Hazarey等^[20]	15/15	18~50		不详		姜黄素400 mg, po,tid	局部涂氯倍他索乳膏, tid	3	6	①②
Yadav等^[21]	20/20	T:37.9±10.5	C:37.9±10.5	T:15/5	C:16/4	姜黄素300 mg, po,qd	地塞米松4 mg+透明质酸酶1 500 IU局部注射, 1周1次	3	3	①④

纳入研究	随机方法	分配隐藏	盲法		结果数据完整性	选择性报告研究结果	其他偏倚
纳入研究	随机方法	分配隐藏	研究和受试者	结果评价者	结果数据完整性	选择性报告研究结果	其他偏倚
Piyush等^[16]	计算机随机	不透明信封	双盲	盲法	完整	低风险	不清楚
Saran等^[17]	鱼缸法	不清楚	双盲	盲法	完整	低风险	不清楚
Ara等^[18]	随机数字表法	不清楚	单盲	盲法	完整	低风险	不清楚
Kopuri等^[19]	不清楚	不清楚	不清楚	不清楚	完整	低风险	不清楚
Hazarey等^[20]	不清楚	不清楚	不清楚	不清楚	完整	低风险	不清楚
Yadav等^[21]	随机数字表法	不清楚	不清楚	不清楚	完整	低风险	不清楚

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