West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (2): 195-202.doi: 10.7518/hxkq.2021.02.011

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Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis

Guo Jincai1(), Xie Hui1(), Wu Hao1, Tong Tiejun2   

  1. 1.Changsha Stomatological Hospital, Changsha 410006, China
    2.Dept. of Mathematics, Hong Kong Baptist University, Hongkong 999077, China
  • Received:2020-07-17 Revised:2020-11-14 Online:2021-04-01 Published:2021-04-09
  • Contact: Xie Hui E-mail:540009728@qq.com;kqyyxh1@126.com
  • Supported by:
    Health Care Special Fund Research Project of Hunan Province(B2020-07);Clinical Pharmacy Project of Medical Research Fund of Hunan Medical Association(HMA202001012);Clinical Medical Technology Innovation Guiding Project of Hunan Province(2020SK53206);Natural Science Foundation of Changsha(kq2014019);Research Project Funding of Changsha Municipal Health and Family Planning Commission(201809);Key R & D Project of Hunan Province(2020SK2137)

Abstract: Objective

This study was performed to review the efficacy of curcumin in the treatment of oral submucous fibrosis systematically.


We searched seven databases, including Web of Science, PubMed, EBSCO, The Cochrane Library, CNKI, WanFang Data, and VIP, to obtain randomized controlled trials related to the treatment of oral submucous fibrosis by curcumin. Each database was searched from inception to 30 June 2019. RevMan 5.3 software was used for the meta-analysis.


Six randomized controlled trials involving 350 patients were included in this study. Meta-analysis showed that curcumin can increase the maximal mouth opening and improve burning sensation compared with placebo treatment. Curcumin was not as effective as the controls in achieving maximal mouth opening after 1 month of treatment. However, no statistically significant difference was observed between the treatments from 2 months to 6 months. Curcumin significantly improved burning sensation compared with the controls after 3 months of treatment. No statistically significant diffe-rence in burning sensation was observed between the curcumin and control groups after 1, 2, and 6 months of treatment.


The current evidence shows that curcumin is an effective treatment for improving maximal mouth opening and burning sensation in patients with oral submucous fibrosis. Given the limited number and low quality of the included studies, however, more high-quality studies are needed to verify these findings.

Key words: oral submucous fibrosis, curcumin, Meta-analysis, evidence-based medicine

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