Role of human papillomavirus in head and neck squamous cell carcinomas

doi:10.7518/hxkq.2017.02.015

Abstract

Abstract:

Human papillomavirus (HPV) is a major causative agent of cervical cancers. Over the past several decades, increasing number of studies established strong association of HPV with a subset of head and neck squamous cell carcinomas (HNSCCs). In the present study, we reviewed evidence, including epidemiology, carcinogens, diagnosis, treatment, and pro-gnosis, showing that HPV-positive HNSCCs exhibit a variety of distinct characteristics for understanding tumor biology and improving cancer treatment.

Key words: human papillomavirus, head and neck squamous cell carcinomas, carcinogene

CLC Number:

R739.8

Guangxue Cui, Xiaolei Gao, Xinhua Liang. Role of human papillomavirus in head and neck squamous cell carcinomas[J]. West China Journal of Stomatology, 2017, 35(2): 187-191.

References 33

[1]	Chai RC, Lambie D, Verma M, et al.Current trends in the etiology and diagnosis of HPV-related head and neck can-cers[J]. Cancer Med, 2015, 4(4):596-607.
[2]	Li W, Thompson CH, Xin D, et al.Absence of human papil-lomavirus in tonsillar squamous cell carcinomas from Chi-nese patients[J]. Am J Pathol, 2003, 163(6):2185-2189.
[3]	Gillison ML, Castellsagué X, Chaturvedi A, et al.Eurogin roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix[J]. Int J Cancer, 2014, 134(3):497-507.
[4]	Dahlstrom KR, Calzada G, Hanby JD, et al. An evolution in demographics, treatment,outcomes of oropharyngeal cancer at a major cancer center[J]. Cancer, 2013, 119(1):81-89.
[5]	Zaravinos A.An updated overview of HPV-associated head and neck carcinomas[J]. Oncotarget, 2014, 5(12):3956-3969.
[6]	Chaturvedi AK, Engels EA, Pfeiffer RM, et al.Human papil-lomavirus and rising oropharyngeal cancer incidence in the United States[J]. J Clin Oncol, 2011, 29(32):4294-4301.
[7]	Forman D, De Martel C, Lacey CJ, et al.Global burden of human papillomavirus and related diseases[J]. Vaccine, 2012, 30(Suppl 5):F12-F23.
[8]	Gillison ML, Koch WM, Capone RB, et al.Evidence for a causal association between human papillomavirus and a sub-set of head and neck cancers[J]. J Natl Cancer Inst, 2000, 92(9):709-720.
[9]	IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human papillomaviruses[J]. IARC Mo-nogr Eval Carcinog Risks Hum, 1994, 90:1-636.
[10]	Moody CA, Laimins LA.Human papillomavirus oncopro-teins: pathways to transformation[J]. Nat Rev Cancer, 2010, 10(8):550-560.
[11]	Friedman JM, Stavas MJ, Cmelak AJ.Clinical and scien-tific impact of human papillomavirus on head and neck can-cer[J]. World J Clin Oncol, 2014, 5(4):781-791.
[12]	Benson E, Li R, Eisele D, et al.The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas[J]. Oral Oncol, 2014, 50(6):565-574.
[13]	Mirghani H, Amen F, Moreau F, et al.Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma[J]. Oral Oncol, 2015, 51(3):229-236.
[14]	De Martel C, Ferlay J, Franceschi S, et al.Global burden of cancers attributable to infections in 2008: a review and synthetic analysis[J]. Lancet Oncol, 2012, 13(6):607-615.
[15]	Ndiaye C, Mena M, Alemany L, et al.HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis[J]. Lancet Oncol, 2014, 15(12):1319-1331.
[16]	Cao J, Zhang ZY, Zhang YX, et al.Human papillomavirus infection and p53 alteration in oral squamous cell carcinoma[J]. Chin J Dent Res, 2000, 3(3):44-49.
[17]	帕提曼, 曹俊, 陈万涛, 等. 口腔鳞状细胞癌高危型人乳头状瘤病毒感染的检测[J]. 上海口腔医学, 2000, 9(4):212-215.
	Patima, Cao J, Chen WT, et al. Detection of high risk human papillomavirus DNA in oral squamous cell carcinoma[J]. Shanghai J Stomatol, 2000, 9(4):212-215.
[18]	张洁莉. HPV感染与头颈部鳞癌的相关性以及对肿瘤预后的影响[D]. 北京: 北京协和医学院, 2010.
	Zhang JL.Human papilloma virus 16/18 infection in head and neck squamous cell carcinoma: incidence, possible me-chanism and prognosis[D]. Beijing: Peking Union Medical College, 2010.
[19]	Akagi K, Li J, Broutian TR, et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability[J]. Genome Res, 2014, 24(2):185-199.
[20]	Ragin CC, Taioli E, Weissfeld JL, et al.11q13 amplifica-tion status and human papillomavirus in relation to p16 ex-pression defines two distinct etiologies of head and neck tumours[J]. Br J Cancer, 2006, 95(10):1432-1438.
[21]	Hu Z, Müller S, Qian G, et al.Human papillomavirus 16 oncoprotein regulates the translocation of β-catenin via the activation of epidermal growth factor receptor[J]. Cancer, 2015, 121(2):214-225.
[22]	Westra WH.Detection of human papillomavirus (HPV) in clinical samples: evolving methods and strategies for the accurate determination of HPV status of head and neck car-cinomas[J]. Oral Oncol, 2014, 50(9):771-779.
[23]	Urban D, Corry J, Rischin D.What is the best treatment for patients with human papillomavirus-positive and -negative oropharyngeal cancer[J]. Cancer, 2014, 120(10):1462-1470.
[24]	Zhang MQ, El-Mofty SK, Dávila RM.Detection of human papillomavirus-related squamous cell carcinoma cytologi-cally and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: a tool for identifying the site of an occult head and neck primary[J]. Cancer, 2008, 114(2):118-123.
[25]	Deng Z, Hasegawa M, Aoki K, et al.A comprehensive eva-luation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous cell carcinoma[J]. Int J Oncol, 2014, 45(1):67-76.
[26]	Chi AC, Day TA, Neville BW.Oral cavity and oropharyn-geal squamous cell carcinoma—an update[J]. CA Cancer J Clin, 2015, 65(5):401-421.
[27]	Zhang Z, Filho MS, Nör JE.The biology of head and neck cancer stem cells[J]. Oral Oncol, 2012, 48(1):1-9.
[28]	Ang KK, Harris J, Wheeler R, et al.Human papillomavirus and survival of patients with oropharyngeal cancer[J]. N Engl J Med, 2010, 363(1):24-35.
[29]	Zhang M, Kumar B, Piao L, et al.Elevated intrinsic cancer stem cell population in human papillomavirus-associated head and neck squamous cell carcinoma[J]. Cancer, 2014, 120(7):992-1001.
[30]	Mannelli G, Gallo O.Cancer stem cells hypothesis and stem cells in head and neck cancers[J]. Cancer Treat Rev, 2012, 38(5):515-539.
[31]	Rietbergen MM, Martens-De Kemp SR, Bloemena E, et al. Cancer stem cell enrichment marker CD98: a prognostic factor for survival in patients with human papillomavirus-positive oropharyngeal cancer[J]. Eur J Cancer, 2014, 50(4):765-773.
[32]	Dalianis T.Human papillomavirus and oropharyngeal can-cer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy (Review)[J]. Int J Oncol, 2014, 44(6):1799-1805.
[33]	Herrero R, Quint W, Hildesheim A, et al.Reduced preva-lence of oral human papillomavirus(HPV) 4 years after biva-lent HPV vaccination in a randomized clinical trial in Costa Rica[J]. PloS One, 2013:e68329.