Abstract:

Objective:The aim of this study is to observe clinical effects of the millimeter wave on oral lichen planus (OLP) and its immune mechanisms.Methods:30 patients with OLP were randomized into the millimeter wave group and the control group. 15 patients in the millimeterwave group were treated with millimeter wave (7.1 mm, 43 GHz, 10 mW/cm2) radiation, while the other 15 patients in the control group were just given soothing treatment. Either before or after the therapy procedure, the clinical manifestations and the T-cell sub-grouping in the peripheral circulation of each patientwere double-blindly evaluated.Results:The pain-soothing effect in the patients treatedwithmillimeterwave wasmuchmore obvious than thatof the control group (P<0.01). The peripheral blood CD8+percent of millimeterwave group decreased greatly (P<0.05), while no obvious CD8+change was observed in the control group (P>0.05). The millimeter wave groupcs CD4+/CD8+improvement was also much more obvious than that of the control group (P<0.05), and its CD4+/CD8+ratio was completely recovered to the normal level.Conclusion: Millimeterwave can effectively relieve OLP patientscpain, and can regulate OLP patientsccellular immune condition. Millimeter wave might provide a new treatment method for OLP.

Key words: millimeter wave, oral lichen planus, T cell subgroups, biological effects