Abstract:

Objective:This study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.Methods:The expression of IL-6 and ICAM-1 was examined using im- munohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient.s inflammatory gingival tissue without treatment of IL-10 was included into the control group.Results:IL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed thatthe expression in the experimental group differed significantly from that in the control group.Conclusion:The exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue.

Key words: interlukine-10, gingival tissue, interlukine-6, intercellular adhesion molecular, immunohistochemistry