Research progress on the biomimetic remineralization of hard tooth tissues based on polyamide-amine dendrimer

doi:10.7518/hxkq.2020.06.015

Abstract

Abstract:

Polyamide-amine (PAMAM) dendrimer, a new hyperbranched macromolecular polymer, is considered an “artificial protein” by many scholars on account of its excellent chemical and biological characteristics. PAMAM has internal cavities and a large number of reactive terminal groups. These structures allow the polymer to be used as a bionic macromoleculethat could simulate the biomimetic mineralization of the natural organic matrix on the surface of tooth tissue. Specifically, PAMAM can beused as an organic template to regulate mineral nucleation and crystal growth; thus, the polymerisa more ideal dental restoration material than traditional allogenic materials. This article reviews research progress on thePAMAM-induced biomimetic mineralization of hard tooth tissues.

Key words: polyamide-amine dendrimer, biomimetic mineralization, hard tooth tissue

CLC Number:

R780.2

Xiang Kezhen, Chen Liang, Yang Deqin. Research progress on the biomimetic remineralization of hard tooth tissues based on polyamide-amine dendrimer[J]. West China Journal of Stomatology, 2020, 38(6): 692-696.

References 39

[1]	罗菁菁, 宁天云, 李全利, 等. 釉质仿生矿化模型的研究[J]. 口腔生物医学, 2016,7(4):173-176.
	Luo JJ, Ning TY, Li QL, et al. A model for biomimetic mineralization of enamel[J]. Oral Biomed, 2016,7(4):173-176.
[2]	Li JH, Yang JJ, Li JY, et al. Bioinspired intrafibrillar mineralization of human dentine by PAMAM dendrimer[J]. Biomaterials, 2013,34(28):6738-6747. doi: 10.1016/j.biomaterials.2013.05.046 URL
[3]	Mai S, Kim YK, Kim J, et al. In vitro remineralization of severely compromised bonded dentin[J]. J Dent Res, 2010,89(4):405-410. doi: 10.1177/0022034510363662 URL
[4]	Mai S, Kim YK, Toledano M, et al. Phosphoric acid esters cannot replace polyvinylphosphonic acid as phosphoprotein analogs in biomimetic remineralization of resin-bonded dentin[J]. Dent Mater, 2009,25(10):1230-1239. doi: 10.1016/j.dental.2009.05.001 URL
[5]	Fan YW, Nelson JR, Alvarez JR, et al. Amelogenin-assisted ex vivo remineralization of human enamel: effects of supersaturation degree and fluoride concentration[J]. Acta Biomater, 2011,7(5):2293-2302. doi: 10.1016/j.actbio.2011.01.028 URL pmid: 21256987
[6]	Guentsch A, Seidler K, Nietzsche S, et al. Biomimetic mineralization: long-term observations in patients with dentin sensitivity[J]. Dent Mater, 2012,28(4):457-464. URL pmid: 22305715
[7]	Prasad M, Butler WT, Qin CL. Dentin sialophosphoprotein in biomineralization[J]. Connect Tissue Res, 2010,51(5):404-417. doi: 10.3109/03008200903329789 URL pmid: 20367116
[8]	Tomalia DA, Baker H, Dewald J, et al. A new class of polymers: starburst-dendritic macromolecules[J]. Polym J, 1985,17(1):117-132.
[9]	Singh P, Gupta U, Asthana A, et al. Folate and folate-PEG-PAMAM dendrimers: synjournal, characterization, and targeted anticancer drug delivery potential in tumor bearing mice[J]. Bioconjug Chem, 2008,19(11):2239-2252. URL pmid: 18950215
[10]	Eichman JD, Bielinska AU, Kukowska-Latallo JF, et al. The use of PAMAM dendrimers in the efficient transfer of genetic material into cells[J]. Pharm Sci Technol Today, 2000,3(7):232-245. doi: 10.1016/s1461-5347(00)00273-x URL pmid: 10884679
[11]	Jia R, Lu Y, Yang CW, et al. Effect of generation 4.0 polyamidoamine dendrimer on the mineralization of demineralized dentinal tubules in vitro[J]. Arch Oral Biol, 2014,59(10):1085-1093. URL pmid: 24997233
[12]	Guo LX, Gao QD. Synjournal and performance of PAMAM-Lys dendrimer[J]. Chem J Chin Univ, 2012, 33(1): 176-181.
[13]	Lungu A, Rusen E, Butac L, et al. Epoxy-mediated immobilization of PAMAM dendrimers on methacrylic hydrogels[J]. Dig J Nanomater Biostruct 2009,4(1):97-107.
[14]	林轩东. 聚酰胺—胺及其纳米复合生物材料诱导牙本质小管的仿生再矿化研究[D]. 南宁: 广西医科大学, 2017.
	Lin XD. The research of polyamidoamine drimer and pamam/n-HAP on the biomimetic remineralization of demineralized dentinal tubules[D]. Nanning: Guangxi Medical University, 2017.
[15]	Gao Y, Liang KN, Li JS, et al. Effect and stability of poly(amido amine)-induced biomineralization on dentinal tubule occlusion[J]. Materials (Basel), 2017,10(4):E384.
[16]	Zhou Y, Yang JJ, Lin ZF, et al. Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine[J]. Colloids Surf B Biointerfaces, 2014,115:237-243. doi: 10.1016/j.colsurfb.2013.11.045 URL pmid: 24362062
[17]	Chen L, Liang KN, Li JS, et al. Regeneration of biomimetic hydroxyapatite on etched human enamel by anionic PAMAM template in vitro[J]. Arch Oral Biol, 2013,58(8):975-980. doi: 10.1016/j.archoralbio.2013.03.008 URL
[18]	Liang KN, Yuan H, Li JS, et al. Remineralization of demineralized dentin induced by amine-terminated PAMAM dendrimer[J]. Macromol Mater Eng, 2015,300(1):107-117. doi: 10.1002/mame.201400207 URL
[19]	Shellis RP, Featherstone JDB, Lussi A. Understanding the chemistry of dental erosion[M]// Monographs in oral science. Basel: S. KARGER AG, 2014: 163-179.
[20]	Zhang H, Yang JJ, Liang KN, et al. Effective dentin restorative material based on phosphate-terminated dendrimer as artificial protein[J]. Colloids Surf B Biointerfaces, 2015,128:304-314. doi: 10.1016/j.colsurfb.2015.01.058 URL pmid: 25703791
[21]	Chen L, Yuan H, Tang B, et al. Biomimetic remineralization of human enamel in the presence of polyamidoamine dendrimers in vitro[J]. Caries Res, 2015,49(3):282-290. doi: 10.1159/000375376 URL pmid: 25924633
[22]	Mukherjee S, Huang CC, Guerra F, et al. Thermodynamics of bisphosphonates binding to human bone: a two-site model[J]. J Am Chem Soc, 2009,131(24):8374-8375. doi: 10.1021/ja902895p URL pmid: 19489581
[23]	Jiang CY, Zurick K, Qin CL, et al. Probing the influence of SIBLING proteins on collagen-Ⅰfibrillogenesis and denaturation[J]. Connect Tissue Res, 2018,59(3):274-286. doi: 10.1080/03008207.2017.1379514 URL pmid: 28910556
[24]	Zhu BG, Li XF, Xu XY, et al. One-step phosphorylated poly(amide-amine) dendrimer loaded with apigenin for simultaneous remineralization and antibacterial of dentine[J]. Colloids Surf B Biointerfaces, 2018,172:760-768. doi: 10.1016/j.colsurfb.2018.09.036 URL pmid: 30261466
[25]	Liang KN, Yuan H, Li JS, et al. Remineralization of demineralized dentin induced by amine-terminated PAMAM dendrimer[J]. Macromol Mater Eng, 2015,300(1):107-117. doi: 10.1002/mame.201400207 URL
[26]	Dickens SH, Flaim GM, Takagi S. Mechanical properties and biochemical activity of remineralizing resin-based Ca-PO₄ cements[J]. Dent Mater, 2003,19(6):558-566. doi: 10.1016/S0109-5641(02)00105-7 URL
[27]	Liang KN, Weir MD, Xie XJ, et al. Dentin remineralization in acid challenge environment via PAMAM and calcium phosphate composite[J]. Dent Mater, 2016,32(11):1429-1440. doi: 10.1016/j.dental.2016.09.013 URL pmid: 27665621
[28]	Liang KN, Xiao SM, Wu JL, et al. Long-term dentin remineralization by poly(amido amine) and rechargeable calcium phosphate nanocomposite after fluid challenges[J]. Dent Mater, 2018,34(4):607-618. URL pmid: 29398109
[29]	Liang KN, Xiao SM, Weir MD, et al. Poly(amido amine) dendrimer and dental adhesive with calcium phosphate nanoparticles remineralized dentin in lactic acid[J]. J Biomed Mater Res Part B Appl Biomater, 2018,106(6):2414-2424. doi: 10.1002/jbm.b.v106.6 URL
[30]	Ge Y, Ren B, Zhou XD, et al. Novel dental adhesive with biofilm-regulating and remineralization capabilities[J]. Materials (Basel), 2017,10(1):E26.
[31]	Xiao SM, Liang KN, Weir MD, et al. Combining bioactive multifunctional dental composite with PAMAM for root dentin remineralization[J]. Materials (Basel), 2017,10(1):E89.
[32]	Vasile E, Serafim A, Petre D, et al. Direct synjournal and morphological characterization of gold-dendrimer nanocomposites prepared using PAMAM succinamic acid dendrimers: preliminary study of the calcification potential[J]. Sci World J, 2014,2014:103462.
[33]	Chen HF, Chen YQ, Orr BG, et al. Nanoscale probing of the enamel nanorod surface using polyamidoamine dendrimers[J]. Langmuir, 2004,20(10):4168-4171. doi: 10.1021/la0303005 URL pmid: 15969412
[34]	Somasundaran P, Markovic B. Interfacial properties of calcium phosphates[M]// Calcium phosphates in biological and industrial systems. Boston: Springer US, 1998: 85-101.
[35]	Wu D, Yang JJ, Li JY, et al. Hydroxyapatite-anchored dendrimer for in situ remineralization of human tooth enamel[J]. Biomaterials, 2013,34(21):5036-5047. doi: 10.1016/j.biomaterials.2013.03.053 URL pmid: 23578556
[36]	Xie FF, Wei XL, Li QR, et al. In vivo analyses of the effects of polyamidoamine dendrimer on dentin biomineralization and dentinal tubules occlusion[J]. Dent Mater J, 2016,35(1):104-111. doi: 10.4012/dmj.2015-209 URL pmid: 26830830
[37]	Oliveira E, Casado M, Faria M, et al. Transcriptomic response of zebrafish embryos to polyaminoamine (PAMAM) dendrimers[J]. Nanotoxicology, 2014,8(Suppl 1):92-99. doi: 10.3109/17435390.2013.858376 URL
[38]	Gao F, Djordjevic I, Pokholenko O, et al. On-demand bioadhesive dendrimers with reduced cytotoxicity[J]. Molecules, 2018,23(4):E796. URL pmid: 29601480
[39]	Majoros IJ, Williams CR, Becker AC, et al. Surface interaction and behavior of poly(amidoamine) dendrimers: deformability and lipid bilayer disruption[J]. J Comput Theor Nanosci, 2009,6(7):1430-1436. doi: 10.1166/jctn.2009.1189 URL pmid: 21379401