Effect of osseointegration in the posterior area by Shenggu pills

doi:10.7518/hxkq.2017.05.010

Abstract

Abstract:

Objective This study aimed to investigate the osseointegration condition by measuring the implant stability quotient (ISQ) to study the effect of osseointegration in the posterior area by Shenggu pills. Methods A total of 101 DENTIUM implants were placed in 48 patients. Fifty implants placed in 24 patients were addressed as usual, whereas 51 implants placed in 24 patients were treated with Shenggu pills. ISQ was tested on the day of surgery and consecutively at 4, 8, and 12 weeks. All data were analyzed. Results The efficacy of the treatment group was no much better than that of control group on the day of surgery and consecutively at 12 weeks with no significant difference (P>0.05). The efficacy of the treatment group was significantly better than that of the control group at 4 and 8 weeks (P<0.05). The implants placed in the mandible were significantly better than those placed in the maxilla (P<0.05). Conclusion Early intake of Shenggu pills could accelerate the implant bone union, improve the implants’ ISQ, and ensure the success rate of the operation.

Key words: osseointegration, implant stability quotient, Shenggu pills

CLC Number:

R282

Cuifen Luo, Guoguang Peng. Effect of osseointegration in the posterior area by Shenggu pills[J]. West China Journal of Stomatology, 2017, 35(5): 498-501.

Figures/Tables 2

References 10

[1]	Glauser R, Sennerby L, Meredith N, et al. Resonance fre-quency analysis of implants subjected to immediate or early functional occlusal loading. Successful vs. failing implants[J]. Clin Oral Implants Res, 2004, 15(4):428-434.
[2]	Glauser R, Ruhstaller P, Windisch S, et al.Immediate occ-lusal loading of Brånemark System ® TiUniteTM implants placed predominantly in soft bone: 4-year results of a pro-spective clinical study[J]. Clin Implant Dent Relat Res, 2005, 7(Suppl l):S52-S59.
[3]	Sjöström M, Sennerby L, Nilson H, et al.Reconstruction of the atrophic edentulous maxilla with free iliac crest grafts and implants: a 3-year report of a prospective clinical study[J]. Clin Implant Dent Relat Res, 2007, 9(1):46-59.
[4]	Misch CE.Contemporary implant dentistry[M]. Holland: Mosby Elsevier, 2008:90.
[5]	Quesada-García MP, Prados-Sánchez E, Olmedo-Gaya MV, et al.Measurement of dental implant stability by resonance frequency analysis: a review of the literature[J]. Med Oral Patol Oral Cir Bucal, 2009, 14(10):e538-e546.
[6]	彭国光, 陈志维. 牙颌创伤治疗学[M]. 北京: 人民卫生出版社, 2011:184-189.
	Peng GG, Chen ZW.Treatments of dentognathic injuries[M]. Beijing: People’s Medical Publishing House, 2011:184-189.
[7]	李学东, 陈斌, 郑创义, 等. 三七总皂甙对骨髓基质细胞成骨分化及成骨作用的调节[J]. 中国骨质疏松杂志, 2009, 15(5):371-373.
	Li XD, Chen B, Zheng CY, et al.Effects of total saponins of panax notoginseng on osteogenesis of rat bone marrow stromal cells[J]. Chin J Osteoporos, 2009, 15(5):371-373.
[8]	Jang YJ, Kim ME, Ko SY. n-Butanol extracts of Panax notoginseng, suppress LPS-induced MMP-2 expression in periodontal ligament fibroblasts and inhibit osteoclastoge-nesis by suppressing MAPK in LPS-activated RAW264.7 cells[J]. Arch Oral Biol, 2011, 56(11):1319-1327.
[9]	Shen Y, Li YQ, Li SP, et al.Alleviation of ovariectomy-induced osteoporosis in rats by Panax notoginseng saponins[J]. J Nat Med, 2010, 64(3):336-345.
[10]	丁佩惠, 唐琪, 陈莉丽, 等. 中药地龙提取液的促成骨作用及对实验性牙槽骨吸收疗效的研究[J]. 浙江大学学报(理学版), 2008, 35(6):684-689.
	Ding PH, Tang Q, Chen LL, et al.Therapeutic effects of Pheretima guillelmi on rat experimental model of alveolar bone resorption and mouse osteoblastic MC3T3-E1 cells[J]. J Zhejiang Univ (Sci Ed), 2008, 35(6):684-689.

基线资料	处理组	对照组	P值
年龄/岁	54.02±7.01	52.41±6.88	0.426 1
性别（男/女）/n	15/9	13/11	0.558 2
糖尿病/n	3	5	0.698 5
骨质疏松症/n	8	7	0.755 5
牙周炎/n	15	17	0.540 3
吸烟史/n	10	8	0.551 0
上颌骨种植体数目/颗	27	25	0.767 5
下颌骨种植体数目/颗	24	25	0.767 5

时间	处理组		对照组
时间	上颌骨（n=27）	下颌骨（n=24）	上颌骨（n=25）	下颌骨（n=25）
术后即刻	65.08±4.87▲☆	72.03±5.02☆	63.42±4.51▲	70.25±4.60
术后4周	63.96±4.44▲●	71.14±4.64●	61.25±4.77▲	66.87±5.01
术后8周	68.91±5.14▲●	77.25±4.81●	65.71±5.02▲	74.40±4.63
术后12周	74.20±4.77▲☆	79.88±5.25☆	73.38±4.98▲	78.12±5.45

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