Abstract:

Objective To investigate the effects of C-reactive protein（CRP） on monocytes chemotaxis ability in vitro. Methods Transwell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP -1 monocytes in each group treated with CRP in different concentration. Results CRP increased the number of attracted monocytes in response to MCP-1（monocyte chemoattractant protein-1）. When treated with CRP concentration at 2 μg·mL-1, the number of chemotactic monocytes increased（P<0.05）. The number of attracted monocytes increased as CRP concentration was elevated（P<0.05）. Conclusion CRP can increase chemotactic ability of THP-1 monocytes in concentration dependent manner.

Key words: periodontitits, monocytes, atherosclerosis, coronary heart disease