华西口腔医学杂志

• 基础研究 • 上一篇    下一篇

桂皮醛对大鼠根尖周炎根管中内毒素水平影响的定量研究

刘红英1, 李文颜1, 郝太国2, 高洪岩1, 马悦3   

  1. 1.大连医科大学附属第二临床学院口腔科; 2.大连市昭鹤口腔门诊; 3.大连医科大学附属第二临床学院检验科, 辽宁大连116023
  • 收稿日期:2007-06-25 修回日期:2007-06-25 出版日期:2007-06-20 发布日期:2007-06-20
  • 通讯作者: 李文颜,Tel: 13941156213
  • 作者简介:刘红英(1975-),女,河北人,硕士

Quantitative Study of Effects of Cinnamaldehyde on Levels of Endotoxin in Root Canals in Rats′Per iapical Per iodontitis Model

LIU Hong- ying1, LI Wen - yan1, HAO Tai - guo2, GAO Hong- yan1, MA Yue3   

  1. 1. Dept. of Stomatology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China; 2. Dalian Shotsuru Dental Clinic, Dalian 116023, China; 3. Clinical Laboratory Department, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
  • Received:2007-06-25 Revised:2007-06-25 Online:2007-06-20 Published:2007-06-20
  • Contact: LI Wen - yan,Tel: 13941156213

摘要:

目的探讨桂皮醛对大鼠根尖周炎根管中内毒素水平的影响, 为桂皮醛作为根管消毒药提供实验依据。方法用75只Wistar大鼠建立根尖周炎模型,随机分为3组,分别为桂皮醛组、甲醛甲酚组、生理盐水组,每组25只。封药前后分别用显色基质鲎试剂法测内毒素的含量。结果根管中内毒素含量结果显示,桂皮醛和甲醛甲酚组明显下降(P<0.05),但两组差异无统计学意义(P>0.05),生理盐水组无明显变化(P>0.05)。结论桂皮醛能有效地降低感染根管中内毒素的含量。

关键词: 桂皮醛, 大鼠, 根尖周炎, 内毒素

Abstract:

Objective To provide experimental evidence for the exploitation of cinnamaldehyde as a kind of root canal disinfectant through studying the effect of cinnamaldehyde on endotoxin in root canals. Methods This experimental model of periapical periodontitis was established with Wistar rats. The 75 rats were divided randomly into 3 groups: Group of cinnamaldehyde, group of formaldehyde cresol formocresol, group of physiological saline. The level of endotoxin was measured by quantitative chromogenic tachypleus amebocyte lysate method before and after sealing the drugs in the root canal. Results The level of endotoxin in the group of cinnamaldehyde and formaldehyde cresol formocresol decreased obviously(P<0.05), and the difference between them was of no significance(P>0.05), the group of physiological saline was of no significant difference(P>0.05). Conclusion Cinnamaldehyde can decrease the level of endotoxin obviously.

Key words: cinnamaldehyde, rat, periapical periodontitis, endotoxin