过氧化氢和复方氯己定致过敏性休克1例及文献分析

doi:10.7518/hxkq.2025.2024324

华西口腔医学杂志 ›› 2025, Vol. 43 ›› Issue (3): 436-441.doi: 10.7518/hxkq.2025.2024324

过氧化氢和复方氯己定致过敏性休克1例及文献分析

钟思雨(), 于竹君, 马蓓蓓, 李丹丹, 王建莉()

口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院药剂科，成都 610041

收稿日期:2024-08-30 修回日期:2024-10-31 出版日期:2025-06-01 发布日期:2025-06-10
通讯作者: 王建莉 E-mail:zhongsiyusisi@163.com;wangjianli0804@163.com
作者简介:钟思雨，药师，硕士，E-mail：zhongsiyusisi@163.com
基金资助:
四川大学华西口腔医院探索与研发项目(RD-01-2023-09)

Hydrogen peroxide and compound chlorhexidine gargle induced anaphylactic shock: a case report and literature review

Zhong Siyu(), Yu Zhujun, Ma Beibei, Li Dandan, Wang Jianli()

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2024-08-30 Revised:2024-10-31 Online:2025-06-01 Published:2025-06-10
Contact: Wang Jianli E-mail:zhongsiyusisi@163.com;wangjianli0804@163.com
Supported by:
Research and Develop Program of West China Hospital of Stomatology, Sichuan University(RD-01-2023-09)

摘要/Abstract

摘要：

过氧化氢溶液和复方氯己定含漱液致严重过敏反应非常少见，大部分医务工作者对其认识不足。本文报道了1例牙周脓肿患者治疗过程中使用过氧化氢和复方氯已定冲洗口腔过程中发生过敏性休克案例，并结合国内外相关文献，以期为过氧化氢和复方氯己定导致的严重不良反应的紧急处置提供参考。

关键词: 过氧化氢溶液, 复方氯己定含漱液, 过敏性休克, 药品不良反应

Abstract:

Severe allergic reactions to hydrogen peroxide solution and compound chlorhexidine gargle are rare, and most medical professionals have limited understanding of such cases. This article reports a case of anaphylactic shock in a patient with a periodontal abscess following oral flushing with hydrogen peroxide and compound chlorhexidine gargle. Drawing on domestic and international literature, it provides a reference for the emergency management of serious adverse reactions caused by these agents.

Key words: hydrogen peroxide solution, compound chlorhexidine gargle, anaphylaxis, adverse drug reaction

中图分类号:

R988.2

钟思雨, 于竹君, 马蓓蓓, 李丹丹, 王建莉. 过氧化氢和复方氯己定致过敏性休克1例及文献分析[J]. 华西口腔医学杂志, 2025, 43(3): 436-441.

Zhong Siyu, Yu Zhujun, Ma Beibei, Li Dandan, Wang Jianli. Hydrogen peroxide and compound chlorhexidine gargle induced anaphylactic shock: a case report and literature review[J]. West China Journal of Stomatology, 2025, 43(3): 436-441.

图/表 2

表 1

表 2

参考文献 41

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病例	性别	年龄/岁	用药原因	过敏史	浓度	不良反应	结局	参考文献
1	男	/	中指刺伤	青霉素	3%	过敏性休克	好转	[9]
2	女	41	腹部疖肿感染	/	3%	过敏性休克	好转	[10]
3	男	42	牙槽脓肿	青霉素	3%	过敏性休克	好转	[11]
4	男	23	拇指受伤	无	3%	过敏性休克	好转	[12]
5	男	64	化脓性胆管炎	/	3%	心跳呼吸骤停	好转	[13]
6	男	70	双肾积水	/	3%	心跳呼吸骤停	好转	[13]
7	男	61	胆管炎	/	3%	心跳呼吸骤停	好转	[13]
8	男	53	肾结石	/	3%	心跳呼吸骤停	好转	[13]
9	男	64	胆管结石	/	/	心跳呼吸骤停	好转	[14]
10	男	32	颅脑缺损	/	/	肺动脉气体栓塞	好转	[15]

病例	性别	年龄/岁	接触源	用药原因	过敏史	浓度	不良反应	结局	参考文献
1	/	20	凝胶	预防新冠病毒	/	0.05%	荨麻疹	好转	[16]
2	男	87	溶液、凝胶	膀胱镜检查	无	0.5%，0.05%	过敏性休克	好转	[17]
3	男	51	溶液、凝胶	膀胱切除术	无	0.5%，0.05%	过敏性休克	好转	[17]
4	男	69	消毒液	检查既往手术过敏原因	青霉素	/	过敏性休克	好转	[17]
5	男	61	消毒液	半结肠切除术	动物毛皮、花粉	0.5%	过敏性休克	好转	[17]
6	男	79	消毒液	胆囊切除术	/	1%	皮疹	好转	[18]
7	男	89	消毒液	腹股沟疝气成形术	/	0.5%	皮疹、低血压	好转	[18]
8	男	9	消毒液	右侧角膜白斑治疗手术	/	0.5%	过敏性休克	好转	[19]
9	男	26	消毒液	包皮环切术	/	1%	过敏性休克	好转	[19]
10	女	31	消毒液	宫颈锥形切除术	/	0.5%	过敏性休克	好转	[19]
11	男	48	消毒液	鼻下动脉粥样硬化斑块切除术	/	0.5%	眼睑荨麻疹	好转	[19]
12	男	15	消毒液	额头伤口消毒	/	0.5%	过敏性休克	好转	[19]
13	男	9	消毒液	上唇伤口消毒	/	0.05%	全身荨麻疹	好转	[19]
14	男	36	消毒液	结直肠切除术	/	2%	低血压	好转	[20]
15	男	16	消毒液	急性淋巴细胞白血病化疗插管	无	2%	过敏性休克	好转	[21]
16	男	58	牙膏	上颌牙龈红斑活检术	无	0.004%	灼烧感	好转	[22]
17	女	69	含漱液	漱口	无	0.2%	荨麻疹	好转	[23]
18	女	65	含漱液	未提及	/	/	口腔炎	好转	[24]
19	女	65	含漱液	未提及	/	/	口腔炎	好转	[24]
20	女	21	含漱液	口腔溃疡漱口	克林霉素	/	过敏性休克	好转	[25]
21	女	77	含漱液	冲洗牙龈脓肿	阿莫西林、头孢类	/	过敏性休克	死亡	[26]
22	男	63	含漱液	拔牙后冲洗牙槽	/	/	过敏性休克	死亡	[27]
23	女	30	含漱液	拔牙后冲洗牙槽	/	/	过敏性休克	死亡	[27]

过氧化氢和复方氯己定致过敏性休克1例及文献分析

Hydrogen peroxide and compound chlorhexidine gargle induced anaphylactic shock: a case report and literature review

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