正颌术中恶性高热1例

doi:10.7518/hxkq.2024.2024200

华西口腔医学杂志 ›› 2024, Vol. 42 ›› Issue (6): 828-831.doi: 10.7518/hxkq.2024.2024200

正颌术中恶性高热1例

李越(), 林洁, 罗薇, 罗楷, 罗林()

口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院麻醉科，成都 610041

收稿日期:2024-05-20 修回日期:2024-06-29 出版日期:2024-12-01 发布日期:2024-11-29
通讯作者: 罗林 E-mail:286418007@qq.com;gdllgdll@126.com
作者简介:李越，主治医师，硕士，E-mail：286418007@qq.com

Malignant hyperthermia during orthognathic surgery: a case report

Li Yue(), Lin Jie, Luo Wei, Luo Kai, Luo Lin()

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Anesthesia, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2024-05-20 Revised:2024-06-29 Online:2024-12-01 Published:2024-11-29
Contact: Luo Lin E-mail:286418007@qq.com;gdllgdll@126.com

摘要/Abstract

摘要：

恶性高热是全身麻醉过程中发生的一种罕见的危及生命的高热反应，危害严重且术前诊断困难。在大多数病例报告中，恶性高热最终通过高热发生后进行的基因检测得以确诊。目前，丹曲林是治疗恶性高热唯一的特效药，可以改善病例的预后。本文报道了1例发生于正颌术中的恶性高热，因发现及时且早期应用丹曲林，最终得以治疗成功，术后生化检查也仅出现肌红蛋白和肌酸激酶的轻微升高。

关键词: 恶性高热, 丹曲林, 麻醉, 七氟烷, 肌红蛋白, 肌酸激酶, 正颌手术

Abstract:

Malignant hyperthermia is a rare life-threatening hyperthermic reaction that occurs during general anesthesia and is difficult to diagnose preoperatively. In most reported cases, final diagnoses of malignant hyperthermia were eventually confirmed by genetic testing after the episodes of hyperthermia. Dantrolene is the only specific medicine with improved treatment outcomes for malignant hyperthermia. In this work, we reported a case of malignant hyperthermia that occurred during orthognathic surgery. Malignant hyperthermia was successfully reversed because of the prompt recognition and specific treatment of dantrolene, and only slight increases in myoglobin and creatine kinase were observed postoperatively.

Key words: malignant hyperthermia, dantrolene, anesthesia, sevoflurane, myoglobin, creatine kinase, orthog-nathic surgery

中图分类号:

R782.05⁺4

李越, 林洁, 罗薇, 罗楷, 罗林. 正颌术中恶性高热1例[J]. 华西口腔医学杂志, 2024, 42(6): 828-831.

Li Yue, Lin Jie, Luo Wei, Luo Kai, Luo Lin. Malignant hyperthermia during orthognathic surgery: a case report[J]. West China Journal of Stomatology, 2024, 42(6): 828-831.

图/表 1

参考文献 22

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正颌术中恶性高热1例

Malignant hyperthermia during orthognathic surgery: a case report

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