华西口腔医学杂志

• 基础研究 • 上一篇    下一篇

口腔癌前损害与鳞癌患者口腔白色念珠菌分离株的磷脂酶活性研究

周敏,曾昕,陈谦明,赵曼,林梅,王晓毅,张纲,李秉琦   

  1. 610041 四川大学华西口腔医学院
  • 收稿日期:2001-10-25 修回日期:2001-10-25 出版日期:2001-10-20 发布日期:2001-10-20
  • 基金资助:
    本课题为国家自然科学基金资助项目(编号30070814)

Phospholipase Activities ofCandida albicansIsolates from Oral Pre-malignant Lesions and Oral Cancers

Zhou Min, Zeng Xin, Chen Qianming, et al   

  1. College of Stomatology,West China University of MedicalSciences
  • Received:2001-10-25 Revised:2001-10-25 Online:2001-10-20 Published:2001-10-20

摘要:

目的:研究口腔粘膜癌前损害和口腔鳞癌患者以及正常人的口腔白色念珠菌分离株的磷脂酶活性。方法: 应用蛋黄培养基沉淀环面积测量法,研究来自于口腔粘膜癌前损害(21株)、口腔鳞癌(15株)患者以及正常人(19 株)共55株白色念珠菌的磷脂酶活性大小。结果:虽然口腔癌前损害组的沉淀环面积平均值较正常对照组为高, 但却无统计学差异;而口腔鳞癌组白色念珠菌的值较口腔癌前损害及正常对照组均小(P<0105),说明口腔鳞癌组分离株的磷脂酶活性较口腔癌前损害组及正常对照组高。结论:在口腔癌前损害和鳞癌患者口腔中的白色念珠菌分离株具有不同的毒力学特点,提示白色念珠菌在这两种具有关联性的疾病中所起的作用可能具有差异。

关键词: 口腔白色念珠菌, 磷脂酶, 癌前损害, 鳞癌

Abstract:

Objective:The aim of this study is to compare activities of phospholipase ofCandida albicansisolatesfrom oral cavities of two groups of patients, including oral pre-malignant lesions and oral cancers.Methods:A total of 55 isolates, including oral pre-ma- lignant lesions (21), oral cancers (15), and normal health control (19), were studied using the precipitate zone assay on the egg yolk agar.Results:No significant difference was found in phospholipase activities between these isolates from normal controls and oral pre-malignant lesions, while the activities of phospholipase of isolates from oral cancers were higher than those of the normal controls.Conclusion:Candida albicansmay play different roles in different manners in these two closely related diseases.

Key words: Candida albicans, phospholipase pre-malignant lesions, squamous cell carcinoma, oral cavity