灼口综合征患者情绪障碍与血清白介素-2和白介素-6浓度的关系

华西口腔医学杂志

灼口综合征患者情绪障碍与血清白介素-2和白介素-6浓度的关系

夏娟,林梅,金早蓉,李秉琦,陈方淳

610041　四川大学华西口腔医学院口腔内科学教研室 (夏　娟,林　梅,李秉琦,陈方淳),深圳市人民医院口腔医疗中心 (金早蓉)

收稿日期:2003-10-25 修回日期:2003-10-25 出版日期:2003-10-20 发布日期:2003-10-20

Correlations among Mood Disorder, Serum Interleukin-2 and Interleukin-6 in Patients with Burning Mouth Syndrome

XIAJuan*,LINMei,JINZaorong,et al.

*Department ofOralMedicine,West China College ofStomatology,Sichuan Univer- sity,Chengdu610041,China

Received:2003-10-25 Revised:2003-10-25 Online:2003-10-20 Published:2003-10-20

摘要/Abstract

摘要：

目的　探讨灼口综合征(BMS)患者血清IL-2和IL-6浓度与情绪障碍间的相关性。方法　采用酶联免疫吸附测定法(ELISA)检测48例BMS患者血清IL-2、IL-6的浓度,并采用汉密顿抑郁量表评定患者的抑郁症状。结果　伴有或不伴有抑郁的BMS患者血清IL-2、IL-6浓度无显著差异,但汉密顿抑郁量表与疼痛程度呈正相关。结论　本研究支持BMS患者与情绪障碍有关,汉密顿抑郁量表可用作临床评定BMS患者的抑郁状态,并为临床治疗提供参考;BMS患者血清IL-2、IL-6的浓度与患者抑郁症状无相关性。

关键词: 灼口综合征, IL-2, IL-6, 情绪障碍

Abstract:

Objective　To examine serum IL-2 and IL-6 levels in BMS patientswith orwithout depression and make clear the relationship between serum IL-2, IL-6 and mood disorder.Methods　Serum IL-2 and IL-6 were examined in 48 BMS patients by means of ELISA. The Hamilton Depression Rating Scale (HDRS) was used to evaluate the depressive symptomatology.Results 　There was no significant difference in serum IL-2 and IL-6 among BMS patients with orwithout depression. Mood disorderwas not correlated to serum IL-2 and IL-6, but positively correlated to pain levels.Conclusion　Depression status may not influence serum IL-2 and IL-6 levels significantly, but it has a relationshipwith BMS. TheHDRS can be used to determine depression status in BMS patients in order to help clinical treatment.

Key words: burning mouth syndrome, IL-2, IL-6, mood disorder

夏娟,林梅,金早蓉,李秉琦,陈方淳. 灼口综合征患者情绪障碍与血清白介素-2和白介素-6浓度的关系[J]. 华西口腔医学杂志.

XIAJuan*,LINMei,JINZaorong,et al.. Correlations among Mood Disorder, Serum Interleukin-2 and Interleukin-6 in Patients with Burning Mouth Syndrome[J]. West China Journal of Stomatology.

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