关键词: 免疫化疗, 口腔鳞癌, 淋巴细胞

Abstract:

Objective　To evaluate the effect of locoregional immunotherapy of interleukin 2 (IL-2) in combination with chemotherapy upon intratumoral lymphocytes in oral squamous cell carcinomas.Methods　Thirty-four patientswith stageT3 orT4 oral squamous cell carcinoma were randomly divided into two groups, and treated with two therapies. 23 cases of them received immunochemotherapy and 11 cases received PVP chemotherapy. Changes ofT lymphocyte subsets and B cells at tumor site in the two groups were compared before and after therapy.Results　The relative numbers of CD4+,CD8+,CD20+before and after treatment in immunochemotherapy were respectively 36.96, 35.65, 28.65 and 56.61,38.52,38.70. The numbers of CD4+, CD20+increased significantly after immunochemotherapy. However, in chemotherapy group, there was no significant difference in numbers of CD4+,CD8+and CD20+cells between pre and post treatment.Conclusion　Immunochemotherapy for oral squamous cell carcinomas may play an important role in increasing local immunity.

Key words: immunochemotherapy, oral squamous cell carcinoma, lymphocyte