华西口腔医学杂志

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冷酸解离-氟离子电极法测定牙膏中总氟含量的评价

王晓灵;程绰约;葛瑶;王勤   

  1. 北京大学口腔医院  预防科,北京 100081
  • 收稿日期:2006-10-25 修回日期:2006-10-25 出版日期:2006-10-20 发布日期:2006-10-20
  • 通讯作者: 王晓灵, Tel: 010-62179977-2543
  • 作者简介:王晓灵(1966-),女,河北人,副研究员,硕士

Evaluation of Acid Diffusion and Fluoride Selective Electrode to Measure the Total Fluoride in Toothpastes

WANG Xiao-ling, CHENG Chuo-yue, GE Yao, WANG Qin   

  1. Dept. of Preventive Dentistry, Peking University School of Stomatology, Beijing 100081, China
  • Received:2006-10-25 Revised:2006-10-25 Online:2006-10-20 Published:2006-10-20

摘要:

 目的  探讨冷酸解离-氟离子电极法测定含氟牙膏中总氟含量的可行性和可靠性。方法  选择市售无氟牙膏和含氟牙膏各4个品种,采用2 mol/L高氯酸、室温、过夜的解离
条件,对无氟牙膏加入标准氟后测定总氟量,对市售含氟牙膏进行总氟测定,以确定此方法的可行性和可靠性。结果  牙膏中使用的氟化物与摩擦剂配伍不同对氟测定结果有影响。冷酸解离-氟离子电极法对于含钙类摩擦剂的无氟牙膏加入标准氟(单氟磷酸钠)后总氟的回收率为99.5%~100.5%,对于市售单氟磷酸钠与钙类摩擦剂配伍的含氟牙膏总氟的测得率在94%以上,此方法的相对标准偏差均小于1.54%。对于摩擦剂为二氧化硅的无氟牙膏加入标准氟(氟化钠)后总氟的回收率为83.4%,对于市售氟化钠与二氧化硅配伍的含氟牙膏中总氟的测得率为89.7%。结论  采用冷酸解离-氟离子电极法测定单氟磷酸钠与钙类摩擦剂配伍的含氟牙膏中的总氟含量,具有准确可靠、简便易行的优点。

关键词: 冷酸解离-氟离子电极法, 含氟牙膏, 氟含量

Abstract:

Objective  To evaluate the reliability of a method of measuring the total fluoride in fluoride-containing toothpastes with acid diffusion and fluoride selective
electrode. Methods  Four brands of commercially available non-fluoride toothpastes and fluoride-containing toothpastes were sampled. Fluoride was extracted from the toothpastes in 2 mol/L HClO4 at room temperature overnight and then subjected to the measurement with fluoride electrode. Results  Fluoride recovery of the non-fluoride toothpastes containing calcium as abrasive by this method was 99.5%-100.5%,more than 94% of total fluoride was measured from the marketed fluoride toothpastes, and the variation coefficient of this method was less than 1.54%. While the abrasive was silicon, the fluoride recovery of the non-fluoride toothpastes was 83.4%, and 89.7% of total fluoride was measured from the marketed fluoride-containing toothpastes. Conclusion  The amount of total
fluoride in the calcium containing toothpaste can be detected simply and accurately measured by acid diffusion and fluoride selective electrode. 

Key words: acid diffusion and fluoride selective electrode, fluoride-containing toothpaste, total fluoride