Advances in titanium dental implant surface modification

doi:10.7518/hxkq.2019.02.002

Abstract

Abstract:

Titanium dental implants have wide clinical application due to their many advantages, including comfort, aesthetics, lack of damage to adjacent teeth, and significant clinical effects. However, the failure of osseointegration, bone resorption, and peri-implantitis limits their application. Physical-chemical and bioactive coatings on the surface of titanium implants could improve the successful rate of dental implants and meet the clinical application requirements. This paper reviews the characteristics of surface modification of titanium implants from the aspects of physics, chemistry, and biology. Results provide information for research and clinical application of dental implant materials.

Key words: titanium, dental implants, surface modification, surface coating

CLC Number:

R783

Bangcheng Yang,Xuedong Zhou,Haiyang Yu,Yao Wu,Chongyun Bao,Yi Man,Lei Cheng,Yao Sun. Advances in titanium dental implant surface modification[J]. West China Journal of Stomatology, 2019, 37(2): 124-129.

References 48

[1]	程巧愉, 谢雨航, 王馨怡 , 等. 牙种植体多种表面处理、改性方法研究及最新进展[J]. 中国口腔种植学杂志, 2016,21(4):189-195.
	Cheng QY, Xie YH, Wang XY , et al. Advances in dental implant surface modification[J]. Chin J Oral Implant, 2016,21(4):189-195.
[2]	Valverde GB, Jimbo R, Teixeira HS , et al. Evaluation of surface roughness as a function of multiple blasting processing variables[J]. Clin Oral Implants Res, 2013,24(2):238-242. doi: 10.1111/clr.2013.24.issue-2 URL
[3]	Linez-Bataillon P, Monchau F, Bigerelle M , et al. In vitro MC3T3 osteoblast adhesion with respect to surface roughness of Ti6Al4V substrates[J]. Biomol Eng, 2002,19(2/3/4/5/6):133-141. doi: 10.1016/S1389-0344(02)00024-2 URL
[4]	Zhang EW, Wang YB, Shuai KG , et al. In vitro and in vivo evaluation of SLA titanium surfaces with further alkali or hydrogen peroxide and heat treatment[J]. Biomed Mater, 2011,6(2):025001. doi: 10.1088/1748-6041/6/2/025001 URL
[5]	Kim HW, Koh YH, Li LH , et al. Hydroxyapatite coating on titanium substrate with titania buffer layer processed by sol-gel method[J]. Biomaterials, 2004,25(13):2533-2538. doi: 10.1016/j.biomaterials.2003.09.041 URL
[6]	Moroni A, Caja VL, Sabato C , et al. Bone ingrowth analysis and interface evaluation of hydroxyapatite coated versus uncoated titanium porous bone implants[J]. J Mater Sci: Mater Med, 1994,5(6/7):411-416. doi: 10.1007/BF00058975 URL
[7]	Cunha A, Renz RP, Blando E , et al. Osseointegration of atmospheric plasma-sprayed titanium implants: influence of the native oxide layer[J]. J Biomed Mater Res A, 2014,102(1):30-36. doi: 10.1002/jbm.a.34667 URL
[8]	da Silva LLG, Ueda M, Silva MM , et al. Corrosion behavior of Ti-6Al-4V alloy treated by plasma immersion ion implantation process[J]. Surf Coat Technol, 2007,201(19/20):8136-8139. doi: 10.1016/j.surfcoat.2006.03.054 URL
[9]	Cao HL, Liu XY, Meng FH , et al. Biological actions of silver nanoparticles embedded in titanium controlled by micro-galvanic effects[J]. Biomaterials, 2011,32(3):693-705. doi: 10.1016/j.biomaterials.2010.09.066 URL
[10]	Wan YZ, Raman S, He F , et al. Surface modification of medical metals by ion implantation of silver and copper[J]. Vacuum, 2007,81(9):1114-1118. doi: 10.1016/j.vacuum.2006.12.011 URL
[11]	Unosson E, Rodriguez D, Welch K , et al. Reactive combinatorial synjournal and characterization of a gradient Ag-Ti oxide thin film with antibacterial properties[J]. Acta Biomater, 2015(11):503-510.
[12]	Xu LX, Leng YX, Zhou HF , et al. Structure and hemocompatibility of titanium oxide films synthesized by continuous or pulsed DC magnetron sputtering[J]. Key Eng Mater, 2005: 288-289, 299-302. doi: 10.4028/www.scientific.net/KEM.288-289 URL
[13]	鄢荣曾, 胡敏 . 颅颌面硬组织植入用钛合金材料的研究进展[J]. 辽宁医学院学报, 2015,36(6):106-109.
	Yan RZ, Hu M . Advances in titanium alloys for cranio maxillofacial hard tissue implantation[J]. J Liaoning Med Univ, 2015,36(6):106-109.
[14]	Qin J, Yang DQ, Maher S , et al. Micro- and nano-structured 3D printed titanium implants with a hydroxyapatite coating for improved osseointegration[J]. J Mater Chem B, 2018,6(19):3136-3144. doi: 10.1039/C7TB03251J URL
[15]	Hu X, Xu RG, Yu XL , et al. Enhanced antibacterial efficacy of selective laser melting titanium surface with nanophase calcium phosphate embedded to TiO₂ nanotubes[J]. Biomed Mater, 2018,13(4):045015. doi: 10.1088/1748-605X/aac1a3 URL
[16]	Diamanti MV, Spreafico FC, Pedeferri MP . Production of anodic TiO₂ nanofilms and their characterization[J]. Physics Procedia, 2013,40:4030-4037.
[17]	Yang BC, Uchida M, Kim HM , et al. Preparation of bioactive titanium metal via anodic oxidation treatment[J]. Biomaterials, 2004,25(6):1003-1010. doi: 10.1016/S0142-9612(03)00626-4 URL
[18]	Chung CJ, Long HY . Systematic strontium substitution in hydroxyapatite coatings on titanium via micro-arc treatment and their osteoblast/osteoclast responses[J]. Acta Biomater, 2011,7(11):4081-4087. doi: 10.1016/j.actbio.2011.07.004 URL
[19]	Miola M, Brovarone CV, Maina G , et al. In vitro study of manganese-doped bioactive glasses for bone regeneration[J]. Mater Sci Eng C Mater Biol Appl, 2014(38):107-118.
[20]	Hu H, Zhang W, Qiao Y , et al. Antibacterial activity and increased bone marrow stem cell functions of Zn-incorporated TiO₂ coatings on titanium[J]. Acta Biomater, 2012,8(2):904-915. doi: 10.1016/j.actbio.2011.09.031 URL
[21]	Ferraris S, Spriano S . Antibacterial titanium surfaces for medical implants[J]. Mater Sci Engi C, 2016(61):965-978.
[22]	Wu QJ, Li JH, Zhang WJ , et al. Antibacterial property, angiogenic and osteogenic activity of Cu-incorporated TiO₂ coating[J]. J Mater Chem B, 2014,2(39):6738-6748. doi: 10.1039/C4TB00923A URL
[23]	Zwilling V, Darque-Ceretti E, Boutry-Forveille A , et al. Structure and physicochemistry of anodic oxide films on titanium and TA6V alloy[J]. Surf Interf Analy, 1999,27(7):629-637. doi: 10.1002/(ISSN)1096-9918 URL
[24]	Lee K, Mazare A, Schmuki P . One-dimensional titanium dioxide nanomaterials: nanotubes[J]. Chem Rev, 2014,114
	( 19):9385-9454.
[25]	Gong DW, Grimes CA, Varghese OK , et al. Titanium oxide nanotube arrays prepared by anodic oxidation[J]. J Mater Res, 2001,16(12):3331-3334. doi: 10.1557/JMR.2001.0457 URL
[26]	Das K, Bose S, Bandyopadhyay A , et al. Surface coatings for improvement of bone cell materials and antimicrobial activities of Ti implants[J]. J Biomed Mater Res Part B Appl Biomater, 2008,87(2):455-460.
[27]	Popat K, Eltgroth M , LaTempa T , et al. Titania nanotubes: a novel platform for drug-eluting coatings for medical implants[J]. Small, 2007,3(11):1878-1881. doi: 10.1002/(ISSN)1613-6829 URL
[28]	Park J, Bauer S, Pittrof A , et al. Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO₂ nanotubes[J]. Small, 2012,8(1):98-107. doi: 10.1002/smll.201100790 URL
[29]	Ribeiro AR, Oliveira F, Boldrini LC , et al. Micro-arc oxidation as a tool to develop multifunctional calcium-rich surfaces for dental implant applications[J]. Mater Sci Eng C, 2015(54):196-206.
[30]	Du Q, Wei DQ, Wang YM , et al. The effect of applied voltages on the structure, apatite-inducing ability and antibacterial ability of micro arc oxidation coating formed on titanium surface[J]. Bioact Mater, 2018,3(4):426-433. doi: 10.1016/j.bioactmat.2018.06.001 URL
[31]	Li YD, Wang WQ, Liu HY , et al. Formation and in vitro/in vivo performance of “cortex-like” micro/nano-structured TiO₂ coatings on titanium by micro-arc oxidation[J]. Mater Sci Eng C, 2018(87):90-103.
[32]	Uhlmann DR, Suratwala T, Davidson K , et al. Sol: gel derived coatings on glass[J]. J Non-Crystal Solid, 1997(218):113-122.
[33]	Wen C, Xu W, Hu WY , et al. Hydroxyapatite/titania sol-gel coatings on titanium-zirconium alloy for biomedical applications[J]. Acta Biomater, 2007,3(3):403-410. doi: 10.1016/j.actbio.2006.10.004 URL
[34]	Olding T, Sayer M, Barrow D . Ceramic sol-gel composite coatings for electrical insulation[J]. Thin Solid Films, 2001
	( 398/399):581-586.
[35]	Nishio K, Neo M, Akiyama H , et al. The effect of alkali- and heat-treated titanium and apatite-formed titanium on osteoblastic differentiation of bone marrow cells[J]. J Biomed Mater Res, 2000,52(4):652-661. doi: 10.1002/(ISSN)1097-4636 URL
[36]	Zhang Y, Chen Y, Kou HC , et al. Enhanced bone healing in porous Ti implanted rabbit combining bioactive modification and mechanical stimulation[J]. J Mech Behav Biomed Mater, 2018(86):336-344.
[37]	Li JH, Wang GF, Wang DH , et al. Alkali-treated titanium selectively regulating biological behaviors of bacteria, cancer cells and mesenchymal stem cells[J]. J Colloid Interf Sci, 2014(436):160-170.
[38]	Ban S, Iwaya Y, Kono H , et al. Surface modification of titanium by etching in concentrated sulfuric acid[J]. Dent Mater, 2006,22(12):1115-1120. doi: 10.1016/j.dental.2005.09.007 URL
[39]	Song W, Song X, Yang CX , et al. Chitosan/siRNA functionalized titanium surface via a layer-by-layer approach for in vitro sustained gene silencing and osteogenic promotion[J]. Int J Nanomedicine, 2015,10:2335-2346.
[40]	Zhong X, Song YJ, Yang P , et al. Titanium surface priming with phase-transited lysozyme to establish a silver nanoparticle-loaded Chitosan/Hyaluronic acid antibacterial multilayer via layer-by-layer self-assembly[J]. PLoS One, 2016,11(1):e0146957 doi: 10.1371/journal.pone.0146957 URL
[41]	Yuan Z, Liu P, Hao YS , et al. Construction of Ag-incorporated coating on Ti substrates for inhibited bacterial growth and enhanced osteoblast response[J]. Colloids Surf B Biointerfaces, 2018(171):597-605.
[42]	Lin HY, Chen JH . Osteoblast differentiation and phenotype expressions on chitosan-coated Ti-6Al-4V[J]. Carbohydr Polym, 2013,97(2):618-626. doi: 10.1016/j.carbpol.2013.05.048 URL
[43]	Chen T, Wang S, He F , et al. Promotion of osseointegration using Protamine/Alginate/Bone morphogenic protein 2 biofunctionalized composite coating on nanopolymorphic titanium surfaces[J]. J Biomedl Nanotechnol, 2018, 14(5): 933-945. doi: 10.1166/jbn.2018.2506 URL
[44]	Kazemzadeh-Narbat M, Kindrachuk J, Duan K , et al. Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections[J]. Biomaterials, 2010,31(36):9519-9526. doi: 10.1016/j.biomaterials.2010.08.035 URL
[45]	Rabea EI, Badawy MET, Stevens CV , et al. Chitosan as antimicrobial agent: applications and mode of action[J]. Biomacromolecules, 2003,4(6):1457-1465. doi: 10.1021/bm034130m URL
[46]	Yang Y, Ao HY, Wang YG , et al. Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes[J]. Bone Res, 2016,4:16027. doi: 10.1038/boneres.2016.27 URL
[47]	Timofeeva L, Kleshcheva N . Antimicrobial polymers: mechanism of action, factors of activity, and applications[J]. Appl Microbiol Biotechnol, 2011,89(3):475-492. doi: 10.1007/s00253-010-2920-9 URL
[48]	Cui XN, Murakami T, Tamura Y , et al. Bacterial inhibition and osteoblast adhesion on Ti alloy surfaces modified by poly(PEGMA-r-phosmer) coating[J]. ACS Appl Mater Interfaces, 2018,10(28):23674-23681. doi: 10.1021/acsami.8b07757 URL