Abstract:

Objective　To observe the distribution of Annexin I and cytosolic phospholipose A2(cPLA2) in the palatal process of dexamethasome teratogenerated mice.Methods　Cutting along the coronary plane of the heads of fetal mice to obtain palate in the 14th, 15th, 16th day of gestation by 10-week-old in-bred mice. The distribution of Annexin I and cPLA2was checked by im- munohistochemical staining.Results　Duringthe fusing of the palatal processes, the staining ofAnnexin I and cPLA2 was positive in the epithelial and mesenchymal cells of the palatal process, and the intensity of staining changed with time.Conclusion　An- nexin I and cPLA2can modulate the development of fetal palate to some extent, and theymay be importantmediators in the devel- opment of cleft palate induced by dexamethasone.

Key words: Annexin I, cytosolic phospholipose A2, cleft palate, immunohistochemical staining