West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (5): 605-611.doi: 10.7518/hxkq.2021.05.017

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Application of platelet-rich fibrin on mandibular third molar extraction: systematic review and Meta-analysis

Bao Mingzhe1(), Liu Wei1, Yu Shurong2, Men Yi1, Han Bo1, Li Chunjie1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.Dept. of Stomatology, Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University, Luzhou 646000, China
  • Received:2020-10-21 Revised:2021-07-09 Online:2021-10-01 Published:2021-10-11
  • Contact: Li Chunjie E-mail:1194164132@qq.com;lichunjie@scu.edu.cn
  • Supported by:
    Sichuan University-Luzhou Municipal Government Strategic Cooperation Research(2018CDLZ-12);Correspondence: Li Chunjie, E-mail: lichunjie@scu.edu.cn

Abstract: Objective

This study aims to analyze the effectiveness of platelet-rich fibrin (PRF) in mandibular third molar extraction and provide suggestions for alleviating postoperative complications.


Pubmed, EMBASE, Web of Science, and SinoMed were searched electronically on February 2020. Randomized controlled trials focusing on PRF usage in mandibular third molar extraction were included. Reviewers assessed the risk of bias in the included literature and extracted data independently using the criteria recommended by the Cochrane Collaboration. Meta-analysis was performed using RevMan 5.3 and STATA 13.0.


Twenty-one studies were included, comprising 991 patients who had mandibular third molar extraction. The topical application of PRF effectively reduced pain after extraction [MD=-12.06, 95%CI (-21.42, -2.71), P=0.01], attenuated post-extraction swelling [MD=-1.42, 95%CI (-2.41, -0.44), P=0.005], and promoted soft tissue hea-ling [MD=0.66, 95%CI (0.34, 0.99), P<0.000 1]. PRF significantly reduced trismus and alveolar osteitis (P<0.05). However, data could not prove whether PRF has any significant positive effect on bone healing compared with the control group (P>0.05).


Limited clinical evidence indicates that applying PRF after mandibular third molar extraction could reduce pain, swelling, trismus and the occurrence of dry socket and promote soft tissue healing. However, the effect of PRF on bone healing requires further large-scale randomized controlled trials and unified measurement criteria.

Key words: platelet-rich fibrin, mandibular third molar extraction, Meta-analysis, systematic review

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