West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (4): 405-412.doi: 10.7518/hxkq.2021.04.005

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Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus

Tang Nan(), Zhang Yuyao, Cheng Juehua, Zhao Zhibai, Fan Yuan()   

  1. Dept. of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing 210029, China
  • Received:2020-07-30 Revised:2021-01-25 Online:2021-08-01 Published:2021-08-10
  • Contact: Fan Yuan E-mail:tang19950819@163.com;fanyuan@ njmu.edu.cn;fanyuan@njmu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(81470748);The Priority Academic Program Development of Jiangsu Higher Education Institutions(2018-87)

Abstract: Objective

This study aimed to determine whether a correlation existed between CXC chemokine ligand 10 (CXCL10)-CXC chemokine receptor 3 (CXCR3) and CC chemokine ligand 17 (CCL17)-CC chemokine receptor 4 (CCR4) in the pathogenesis of oral lichen planus (OLP).


Peripheral blood of OLP patients (non-erosive and erosive groups) and healthy controls were collected, and T cells were isolated and purified. T cells were co-cultured with three groups: blank, anti-CXCR3, and anti-CCR4. CXCR3 and CCR4 expression were detected by flow cytometry, and CXCL10 and CCL17 were detected by enzyme-linked immunosorbent assay, respectively.


The purities of T cells were all >95% in the three groups (P>0.05). Receptor expression showed that CXCR3 and CCR4 in the anti-CXCR3 group was downregulated in OLP compared with the blank group (P>0.05). The level of CCR4 in the anti-CCR4 group was significantly downregulated (P<0.05), and CXCR3 was upregulated (P>0.05). Ligand analysis results showed that CXCL10 in the anti-CXCR3 group was significantly downregulated in OLP compared with the blank group (P<0.05), and CCL17 was also downregulated (P>0.05). CCL17 in the anti-CCR4 group was significantly downregulated (P<0.05), and CXCL10 was upregulated (P>0.05). The trend of receptors and ligands in controls was consistent with OLP, but no significant difference existed between the antagonistic and the blank groups (P>0.05).


Two axes interact with each other in the pathogenesis of OLP and may play different roles in its occurrence and development.

Key words: oral lichen planus, CXC chemokine receptor 3, CXC chemokine ligand 10, CC chemokine receptor 4, CC chemokine ligand 17

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