华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (2): 218-223.doi: 10.7518/hxkq.2020.02.018

• 综述 • 上一篇    下一篇

促红细胞生成素肝细胞激酶受体及其膜结合配体相关因子在口腔疾病中的表达及作用机制的研究进展

王琦1, 刘琰2, 赵云1, 孙立众1, 王琳璇1, 韩梅1, 米方林1   

  1. 1. 川北医学院口腔医学系,南充 637000
    2. 川北医学院附属医院修复科,南充 637000
  • 收稿日期:2019-04-05 修回日期:2019-07-29 出版日期:2020-04-01 发布日期:2020-04-15
  • 作者简介:王琦,硕士,E-mail:273489903@qq.com
  • 基金资助:
    四川省教育厅科研项目(15ZA0210);南充市研发资金项目(16YFZJ0123)

Research progress on the expression and function of erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins in oral-related diseases

Wang Qi1, Liu Yan2, Zhao Yun1, Sun Lizhong1, Wang Linxuan1, Han Mei1, Mi Fanglin1   

  1. 1. Dept. of Stomatology, North Sichuan Medical College, Nanchong 637000, China
    2. Dept. of Prosthodontics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
  • Received:2019-04-05 Revised:2019-07-29 Online:2020-04-01 Published:2020-04-15
  • Supported by:
    Scientific Research Projects of Sichuan Education Department(15ZA0210);Research and Development Fund Project of Nanchong City(16YFZJ0123)

摘要:

促红细胞生成素肝细胞激酶受体及其膜结合配体(Eph/ephrin)可以通过细胞与细胞间短距离的信号传导,参与调节生长发育,促进疾病发生发展的各个过程。研究Eph/ephrin与口腔相关疾病的机制可以为口腔疾病的治疗提供新的思路。近年来,针对Eph/ephrin通路调控口腔相关疾病,尤其是在牙周疾病防治、正畸骨改建以及口腔肿瘤的生物学治疗领域的研究逐渐深入,本文即对这3个方面的研究进展进行综述。

关键词: 促红细胞生成素肝细胞激酶受体及其膜结合配体, 牙周炎, 正畸, 肿瘤

Abstract:

Erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins (Eph/ephrin) can participate in the regulation of growth and development and promote the development of diseases through short-distance signal transduction between cells. To study the mechanism of Eph/ephrin and oral-related diseases, we provided a new theoretical basis and a strategy for the treatment of oral diseases. The Eph/ephrin pathway has been used to regulate oral diseases, especially in periodontal disease prevention, orthodontic bone reconstruction, and biological treatment of oral tumors. This paper reviews the research progress of Eph/ephrin pathway in oral-related diseases.

Key words: erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins, periodontitis, orthodontics, tumor

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