锶成骨机制的研究进展

doi:10.7518/hxkq.2020.06.016

摘要/Abstract

摘要：

锶元素在大自然中以化合物的形式广泛存在,是生物体内的一种必需微量元素,对骨代谢具有重要的调节作用。锶元素在周期表中位于第4周期、第ⅡA族,与钙同族,其化学结构和极性与钙十分相似。锶能够通过钙离子受体介导一系列成骨相关通路诱导间充质干细胞向成骨细胞分化,促进成骨细胞的成骨作用,同时抑制破骨细胞活性,减少骨吸收从而促进成骨。近年来学界对锶成骨作用机制广泛研究,本文旨在对锶成骨信号机制的研究进行总结,为其临床应用提供理论基础。

关键词: 锶, 骨代谢, 作用机制

Abstract:

Strontium (Sr) is an essential trace element and widely exists in nature. It plays an important role in the in vivo regulation of bone metabolism. Sr locates below Fe in the periodic table, and its chemical structure and polarity are similar to those of Ca. It can induce bone mesenchymal stem cells to differentiate into osteoblasts by inhibiting the activity of osteoclasts and reducing bone resorption. It promotes bone formation through a series of related pathways. The mechanism of Sr regulation of bone metabolism has been extensively researched in recent years. The current study aims to investigate the mechanism of Sr and provide a theoretical basis for its clinical application.

Key words: strontium, bone metabolism, mechanism of action

中图分类号:

Q593⁺.6

钟宁莹, 王丽萍. 锶成骨机制的研究进展[J]. 华西口腔医学杂志, 2020, 38(6): 697-703.

Zhong Ningying, Wang Liping. Research progress in the osteogenetic mechanism of strontium[J]. West China Journal of Stomatology, 2020, 38(6): 697-703.

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