头颈部肿瘤休眠机制的研究进展

doi:10.7518/hxkq.2018.01.018

华西口腔医学杂志 ›› 2018, Vol. 36 ›› Issue (1): 92-98.doi: 10.7518/hxkq.2018.01.018

头颈部肿瘤休眠机制的研究进展

高晓磊¹(), 梁新华¹, 汤亚玲²()

1.口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院颌面外科门诊
2.病理科,成都 610041

收稿日期:2017-03-22 修回日期:2017-11-22 出版日期:2018-02-07 发布日期:2018-02-01
作者简介:
高晓磊,硕士,E-mail:gxlztl2009@163.com
基金资助:
[基金项目] 国家自然科学基金（81772891）

Mechanisms and implications of cancer cell dormancy in head and neck carcinoma

Xiaolei Gao¹(), Xinhua Liang¹, Yaling Tang²()

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2017-03-22 Revised:2017-11-22 Online:2018-02-07 Published:2018-02-01
Supported by:
Supported by: The National Natural Science Foundation of China (81772891).

摘要/Abstract

摘要：

癌症术后患者在数年甚至数十年后可见局部复发及远处转移的现象,近来被人们定义为肿瘤的休眠。尽管有很多文献已报道相关内容,但肿瘤休眠及微小残留病的生物学和发病机制仍然不清。目前,肿瘤休眠的机制大致包括3种：血管生成性休眠、免疫性休眠及肿瘤细胞的休眠。本文主要讨论调控肿瘤休眠的潜在机制,重点探讨播散肿瘤细胞（DTC）及其与周围微环境的相互作用。此外,对残留肿瘤细胞的再激活机制进行了阐述,如头颈部肿瘤模型中淋巴结内的肿瘤细胞的再激活。

关键词: 肿瘤细胞休眠, 播散肿瘤细胞, 头颈部肿瘤, 缺氧, 淋巴结转移

Abstract:

Disease metastasis and relapse in many cancer patients several years (even decades) after surgical remission have been recently acknowledged as cases of cancer dormancy. Although cases of minimal residual disease are well documented, knowledge on its biological mechanisms and clinical implications remains limited. To date, numerous reviews have summarized the three potential models that may explain this phenomenon, including the angiogenic, immunologic, and cellular dormancy. In this study, we discuss newly uncovered mechanisms governing tumor cell dormancy in head and neck cancer, emphasizing on the crosstalk between dormant tumor cells and their microenvironments. Additionally, we explore the mechanisms on the reactivation of dormant residual tumor cells in anatomical sites, including the lymph nodes and bone marrow.

Key words: cancer dormancy, disseminated tumor cell, head and neck cancer, hypoxia, lymph-node metastasis

中图分类号:

R739.8

高晓磊, 梁新华, 汤亚玲. 头颈部肿瘤休眠机制的研究进展[J]. 华西口腔医学杂志, 2018, 36(1): 92-98.

Xiaolei Gao, Xinhua Liang, Yaling Tang. Mechanisms and implications of cancer cell dormancy in head and neck carcinoma[J]. West China Journal of Stomatology, 2018, 36(1): 92-98.

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头颈部肿瘤休眠机制的研究进展

Mechanisms and implications of cancer cell dormancy in head and neck carcinoma

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