Association between chronic periodontitis and hyperlipidemia: a Meta-analysis based on observational studies

doi:10.7518/hxkq.2017.04.015

Abstract

Abstract:

Objective The aim of this study is to evaluate the relationship between periodontitis and hyperlipidemia risks through Meta-analysis. Methods Two researchers conducted an electronic search on PubMed, Cochrane Library, Embase, CBM, CNKI, Wanfang and VIP databases established until July 2016 for observational studies on the association between periodontitis and hyperlipidemia. The language used was limited to Chinese and English. After data extraction and quality evaluation of included trials, Meta-analysis was conducted using the RevMan 5.3 software. The GRADE 3.6 software was used to evaluate the quality level of the evidence.Results Six case-control studies and one cohort study were included. The results of Meta-analysis showed that serum triglyceride (TG) in patients with periodontitis was significantly higher than that of the periodontal health group (MD=50.50, 95% confidence interval=39.57-61.42, P<0.000 01), as well as serum total cho-lesterol (TC) (MD=17.54, 95% confidence interval=10.91-24.18, P<0.000 01). Furthermore, the risks of TG and TC in the serum of patients with chronic periodontitis were 4.73 times (OR=4.73, 95% confidence interval=2.74-8.17, P<0.000 01) and 3.62 times (OR=3.62, 95% confidence interval=2.18-6.03, P<0.000 01) of that of periodontal healthy patients. No significant difference was observed between the group with high-density lipoprotein cholesterol (HDL-C) and that with low density lipo-protein cholesterol (LDL-C). Conclusion Current evidence indicates that a correlation exists between chronic periodontitis and hyperlipidemia, and chronic periodontitis is an independent risk factor for hyperlipidemia, especially for TC and TG in serum.

Key words: chronic periodontitis, hyperlipidemia, risk factors, Meta-analysis

CLC Number:

R781.4

Lianhui Yang, Meifei Lian, Zhongyue Hu, Yunzhi Feng. Association between chronic periodontitis and hyperlipidemia: a Meta-analysis based on observational studies[J]. West China Journal of Stomatology, 2017, 35(4): 419-426.

Figures/Tables 9

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文献	国家	研究类型	样本量（牙	人群	年龄/岁	牙周炎	校正因素	结局指标	NOS
文献	国家	研究类型	周炎/健康）	来源	年龄/岁	分级	校正因素	结局指标	分数
Moeintaghavi等^[5]	伊朗	病例对照	40/40	医院	牙周炎组32.32±9.2;	中、重度	年龄,性别,其他	TC,TG,HDL,	6
					健康组31.4±7.6		相关系统疾病	LDL
Zhou等^[8]	中国	病例对照	40/20	医院	>40	中、重度	年龄,其他相关的	TC,TG,HDL,	7
							系统病	LDL,PI,BOP,
								PPD, CAL
Cutler等^[10]	朝鲜	病例对照	26/25	牙学院	>25	重度	年龄,性别,种族	TC,TG,血清	8
								IgG,LPS的反应
Lösche等^[11]	德国	病例对照	39/40	医院	牙周炎组54.8±3.1;	中、重度	年龄,性别,吸烟	TC,TG,HDL,	7
					正常组55.4±2.8		史	LDL,血糖
Machado等^[12]	巴西	病例对照	30/30	医院	>20	中、重度	年龄,性别,其他	年龄,BMI,TC,	7
							相关系统疾病	TG,HDL,LDL,
								血糖,牙缺失
Golpasand Hagh等^[21]	伊朗	病例对照	45/45	医院	牙周炎组34.11±4.71;	未明确	年龄,性别	TC,TG,HDL,	7
					健康组35.36±5.05			LDL,血糖
Taleghani等^[22]	伊朗	队列研究	26/26	医院	牙周炎组45±12.2;	中、重度	年龄,BMI,性	TC,TG,HDL,	4
					正常组48±11.6		别,日常活动率,	LDL
							吸烟饮食,家族血
							脂水平