Abstract:

Objective　The purpose of this studywas to observe the behavior of bone formation around the titanium-hollow porous cylinder implant composed of bovine bone morphogentic protein(bBMP).Methods　Porous-hollow cylinder titanium im- plant composed of bBMP was implanted into mandibule of dogs. Multiple fluorescentwas labeled at different times and then LSCM was used to observe the newly formed bone around the complex implant.Results　The newly formed bone around the complex im- plant in experimental group was more obvious than that in other groups.Conclusion　Earlier, longer and more new-bone forma- tion can be induced by porous-hollow cylinder titanium implant composed of bBMP, and LSCM is an effective method to observe new bone formation around implant.

Key words: laser scanning confocal microscope, bone morphogenetic protein, implant, osseointegration