Research progress on two-component signal transduction systems in Porphyromonas gingivalis

doi:10.7518/hxkq.2021.01.013

Abstract

Abstract:

Porphyromonas gingivalis (P. gingivalis), a Gram-negative oral anaerobe, is considered to be a major pathogenic agent involved in the onset and progression of chronic periodontitis. P. gingivalis must be able to perceive and respond to the complicated changes in host to survive the environmental challenges, in which the two-component signal transduction systems (TCSs) play critical roles by connecting input signals to cellular physiological output. Canonical TCS consists of a sensor histidine kinase and a cognate response regulator that functions via a phosphorylation cascade. In this review, the roles of TCSs in P. gingivalis were demonstrated by illustrating the target genes and modulation modes, which may help elucidate the underlying mechanisms in future studies.

Key words: Porphyromonas gingivalis, two-component signal transduction systems, gene regulation

CLC Number:

R 37

Yao Ke, Cai Jingyi, Zhao Lei, Wu Yafei, Zhao Zhihe, Shen Daonan. Research progress on two-component signal transduction systems in Porphyromonas gingivalis[J]. West China Journal of Stomatology, 2021, 39(1): 88-93.

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