Abstract:

Objective To study the expression of inhibitor- 1 of DNA binding/differentiation- 1（Id- 1） and thrombospondin- 1（TSP- 1） genes in mucoepidermoid carcinoma of different malignant degree and analyze the relationship between them. Methods Using immunohistochemistry（IHC） staining technique, TSP - 1 and Id - 1 proteins in the mucoepidermoid carcinoma of different malignant degree, including well - differentiated, moderately differentiated and poorly differentiated mucoepidermoid carcinoma, and normal salivary gland tissues were detected. Results The positive rate of Id- 1 and TSP- 1 in normal salivary glands were apparently lower than that in malignant mucoepidermoid carcinoma（P=0.000, P=0.013）. The positive rate of Id- 1 in moderately and poorly differentiated mucoepidermoid carcinoma was higher than that of the well- differentiated（P=0.001, P=0.002）. However, the positive expression of Id- 1 showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinoma（P>0.05）.The positive rate of TSP- 1 in poorly differentiated mucoepidermoid carcinoma was less than that of the well- differentiated（P=0.014）. The positive expression of TSP- 1 showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinoma（P>0.05）, and the positive expression of it also showed no relationship between the moderately and well differentiated mucoepidermoid carcinoma（P >0.05）. The expression of Id - 1 and TSP - 1 showed negative correlation（r=- 0.394, P=0.002）. Conclusion The expression of TSP- 1 may inhibit the development of the mucoepidermoid carcinoma, contrarily, the expression of Id- 1 may prompt the development of the mucoepidermoid carcinoma. The expression of Id- 1 and TSP- 1 has negative correlation.

Key words: mucoepidermoid carcinoma, thrombos - pondin- 1, inhibitor- 1 of DNA binding/differentiation- 1