Abstract:

Objective To compare the influence of propofol and isoflurane on pro- inflammatory and anti- inflammatory cytokine response to perioperative period of tongue cancer surgery. Methods Twenty- four adult patients undergone the operation of tongue cancer were assigned to two groups randomly, propofol group （ Group P） and isoflurane grou（p Group I）. In group P, anesthesia was induced with fentanyl 2- 3 μg/kg, propofol 2 mg/kg, atracurium 0.6 mg/kg and maintained with propofol 5- 8 mg·kg- 1·h- 1 and inhalation of 50% nirous oxid（e N2O∶O2=50%∶50%）. In group I, anesthesia was induced with 3%- 4% isoflurane, fentanyl 2- 3 μg/kg, diazepam 0.06- 0.1 mg/kg, atracurium 0.6 mg/kg and maintained with inhalation of 50% N2O and isofluran（e ended- tidal isoflurane was maintained at 0.6%）, in two groups atracurium was given intermittently. Blood samples were taken from peripheral vein before anesthesia （ T0）, at the end of operatio（n T1）, 24（h T2）and 48（h T3）after operation for determination of serum IL- 6 and IL - 10 concentrations. The mean arterial pressure （ MAP） and body temperature in two groups were recorded. Results IL- 6 and IL- 10 levels increased significantly in two groups at T1, T2 and T3 compared with T（0 P<0.01）. The increasing trend of IL- 6 and IL- 10 levels were similar in both groups, whereas the level of IL- 6 at T1 in propofol group was lower than that of isoflurane group significant（ly P<0.01）, however the level of IL- 10 was much higher in propofol group than that of isoflurane group at T1 and T（2 P<0.05）. Conclusion The influence of total  intravenous anesthesia of propofol on post- operation inflammatory response is much gentler than isoflurane.

Key words: propofol, isoflurane, interleukins, tongue tumor