West China Journal of Stomatology

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Effect on Xenograft of Nude Mouse by Combination Therapy of nm23-H1 and Protein-cisplatin

ZHI Ke-qian1, CHEN Wei-hui2, WEN Yu-ming3   

  1. 1. Dept. of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; 2. Dept. of Oral and Maxillofacial Surgery, Xiehe Hospital Affiliated to Fujian Medical University, Fuzhou 350001, China; 3. Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2006-04-25 Revised:2006-04-25 Online:2006-04-20 Published:2006-04-20

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Abstract:

 Objective  To study the effect of protein-cisplatin and nm23-H1 therapy on the tumor of nude mouse. Methods  The 15 BALB/C female mice were divided into three groups, control group, protein-cisplatin group and protein-cisplatin+nm23-H1 plasmid group. Tca8113 were injected into the mice subcutaneously with the concentration of 3.1×106 cells/mL. After two weeks, the mixture of lipofectin and nm23-H1 was injected around xenograft of nude mouse. After three days, the protein-cisplatin was injected around xenograft. The weight of mouse, the volume and the weight of xenograft were measured. Results  The weight of mouse was lightest in control group. The volume and weight of the transplanted tumor were lightest in nm23-H1+protein-cisplatin group. Conclusion  The combination therapy of nm23-H1 and protein-cisplatin can effectively inhibites the growth of xenograft in nude mouse.

Key words: nm23-H1, 0cisplatin, xenograft

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