West China Journal of Stomatology

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Quantitative Study of Osteoclastic Related Factors in the Process of Bone Reconstruction

CHANG Xin1, HOU Zhi-ming2, SIBATA Yasuaki3，TSUKAZAKI Tomoo3，YAMAGUCHI Akira3   

  1. 1. Dept. of Oral Science, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China; 2. Dept. of Orthodontics, Stomatological School of China Medical University, Shenyang 110002, China; 3. Division of Oral Pathology and Biomedical Engineering，Dept. of Developmental and Reconstructive Medicine, Biomedical Sciences of Nagasaki University Graduate School，Nagasaki 852-8588, Japan
  • Received:2006-04-25 Revised:2006-04-25 Online:2006-04-20 Published:2006-04-20

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Abstract:

Objective  To detect the expression of osteoclast related factors, tumor necrosis factor-α（TNF-α）, receptor  activator of NF-?资B ligand（RANKL） and tartrate-resistant acid phosphatase（TRAP）, in the process of bone remodeling. Methods  8-week-old male C57BL/6J mice were employed in this study to detect the expression of osteoclast related factors by real time PCR. Results  TNF-α, RANKL and TRAP were up regulated in the process of bone remodeling, they reached the peak on day 2，5 and 10 individually after injury. Conclusion  Osteoclast related factors also participate in bone remodeling, which depends on the delicate balance between bone formation and bone resorption.

Key words: tumornecrosisfactor, receptoractivatorofNF-κBligand, tartrate-resistantacidphosphatase, realtimepolymerasechainreaction, boneremodeling

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