Abstract:

Objective　To study the oncogene transcriptor c-myc, stimulatory protein 1 (SP1) expression in ameloblastoma (AB) and their relation with telomerase reverse transcripase (hTERT), and to investigate the clinical biological characteristics of AB.Methods　The expressionwas observed in AB by in situ hybridization and SPmethod.Results　The positive rates of c-myc mRNA, hTERTmRNA and SP1 protein were 81·5%(44/54)、94·4%(51/54) and 83·3%(45/54), respectively. Their positive rates increased as AB recurred and transformed malignantly. A strong correlation was found between hTERT and c-myc, hTERT and SP1 (rs=0·853,P<0·001;rs=0·900,P<0·001).Conclusion　Activity of telomerase plays an important role in the tu- morigenesis development of AB. Increasing of hTERT expression may be related to c-myc and SP1. The expression of these three parameters has a significant correlation with the clinical biological characteristics of AB.

Key words: ameloblastoma, odontogenic keratocyst, telomerase reverse transcriptase, cellular oncogene, stimulatory protein 1