West China Journal of Stomatology

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Expression and Implication of Pgp, MRP, LRP, GST-π, TopoⅡαin Tongue Squamous Cell Carcinoma

LENG Wei- dong,WANG Da-zhang,FENG Ge,HEJia   

  1. KeyLab.ofOral Biomedical Engineering,Ministry ofEducation,Sichuan Uni- versity,Chengdu610041,China
  • Received:2004-02-25 Revised:2004-02-25 Online:2004-02-20 Published:2004-02-20


Objective To explore the correlation of chemotherapy efficacy in tongue squamous cell carcinoma(SCC) with ex- pression level of P-glycoprotein(Pgp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathiones-tranferase (GST-π), DNAtopo-isomeraseⅡα(TopoⅡα).Methods The expression patterns of Pgp, MRP, LRP, GST-πand TopoⅡαin 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohisto- chemically labelled streptavidin bioein method (LsAB).Results The expression ratios of Pgp, MRP, LRP, GST-πand TopoⅡ αin pre-chemotherapy cases were 47·5%, 50%, 35%, 45%, 82·5%, respectively. No relations between expression of Pgp, MRP, LRP, GST-π, TopoⅡαand clinic indexes were established (P>0·05). Expression ratios of Pgp, MRP in post-chemo- therapy cases were higher than that in pre-chemotherapy cases (P<0·05). Expression of Pgp and MRP showed relevance with drug resistance (P<0·05). The co-expressionwas common, the ratios of co-expression of Pgp, MRP, GST-πandMRP, GST-π in chemotherapy non-responders were 40% and 50%, respectively, but 0 in responders.Conclusion The intrinsic multidrug resistance of tongue SCC is relevant to the effects of Pgp, MRP, GST-π.

Key words: tongue sequamous cell carcinoma, multidrug resistance, P-glycoprotein, multidrug resistance-associated protein, glutathione-S-tranferase