Effects of Cucurbitacin BE Polylactic Acid Nanoparticles on Human Oral Squamous Carcinoma Cell Lines

West China Journal of Stomatology

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Effects of Cucurbitacin BE Polylactic Acid Nanoparticles on Human Oral Squamous Carcinoma Cell Lines

Yang Kai, Wang Changmei, Wen Yuming, Li Longjiang, et al

Yang Kai Department ofStomatology, the First MedicalHospital, ChongqingMedicalUniversity Wang Changmei, Wen Yuming, Li Longjiang, et al West China College ofStomatology, Sichuan University

Received:2002-08-25 Revised:2002-08-25 Online:2002-08-20 Published:2002-08-20

Abstract

Abstract:

Objective:The aim of this study was to study cytotoxic effects of cucurbitacin BE polylactic acid nanoparticles (CuBE-PLA- NP) on human oral squamous carcinoma cell lines Tca8113 (tongue carcinoma) and BcaCD885 (buccal carcinoma).Methods: The chemosensitivity of Tca8113 and BcaCD885 to CuBE-PLA-NP and CuBEwas tested usingMTTassay, the inhibitory rate and 50% inhibition concentrations values (IC-50) of these two drugs against these two cancer cell lineswere evaluated in 1,2,3,4,5, 6,7 and 8 days with different concentrations.Results:Both CuBE-PLA-NP and CuBE showed very high anti-cancer effects on Tca8113 and BcaCD855, and the anticancer efficacy of these two drugswas dose- and time-dependent.Conclusion:The effects of CuBE-PLA-NP on lymph nodes of metastatic cancer cells were higher than that of CuBE.

Key words: cucurbitacinBE polylactic acid, nanoparticles, oral carcinoma, cervical lymph node metastasis, targeted chemotherapy, MTT assay

Yang Kai, Wang Changmei, Wen Yuming, Li Longjiang, et al. Effects of Cucurbitacin BE Polylactic Acid Nanoparticles on Human Oral Squamous Carcinoma Cell Lines[J]. West China Journal of Stomatology.

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Effects of Cucurbitacin BE Polylactic Acid Nanoparticles on Human Oral Squamous Carcinoma Cell Lines

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