West China Journal of Stomatology
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Zhao Yunfu , Jiang Xiaozhong , Liu Yuan , et al
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Abstract:
The aim of this study was to observe whether vasoactive intestinal polypeptide (VIP) participated in the attack of trigeminal neuralgia , and to understand further its pathogenetic mechanism.Methods :Sixteen patients were studied. During the at2 tacks the venous blood was sampled from both the external jugular vein and cubital fossa vein ipsilateral to the pain , and after op2 erations the venous blood from the external jugular vein was sampled again , the external jugular vein blood of eleven normal volun2 teers was collected as the control. Plasma levels of VIP were determined using sensitive radioimmunoassays.Results :During the at2 tacks of trigeminal neuralgia the levels of VIP in the external jugular vein blood were significantly higher than that in the cubital fossa vein blood , postoperative external jugular vein blood and the external jugular vein blood of normal volunteers.Conclusion : VIP indeed participates in the attack of trigeminal neuralgia in the local region , the role of VIP may be relating to enhancing the effects of substance P in local neurogenic inflammation.
Key words: trigeminal neuralgia, vasoactive intestinal polypeptide, radioimmunoassay
Zhao Yunfu,Jiang Xiaozhong,Liu Yuan,et al. Observation of Vasoactive Intestinal Polypeptide in Patients with Trigeminal Neuralgia : A 16-cases Report[J]. West China Journal of Stomatology.
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