Abstract:

Objective:This study was designed to testwhat are the suitable drugs for sclerotherapy and investigate the formation mecha- nism of cavernous hemagiomas.Methods:A total of 84 rabbits were selected for this study, and divided into 6 groups, including one control group and five experimental groups. We selected auricular veins of rabbits as the location of injection. The rabbits of the control were injected with physiological saline, and the rabbits of the experimental groupswere injected respectively with vari- ous drugs, including 5% sodium morrhuate, 10% alum, pinyungmycin, leurocristine and the combination of pinyungmycin and dexamethasone. Histopathological changeswere analyzed after3, 7, 14, 21, 28, 35 days of sclerotherapy.Results:According to histopathological changes of tissue, 5% sodium morrhuate, 10% alum, and the combination of pinyungmycin and dexamethasone produced bettereutherapeutic effects, when comparingwith othermethods. However, 5% sodiummorrhuate caused tissue necrosis of the injection site.Conclusion:The combined therapy of pinyungmycin and dexamethasone produced excellent scleritic effects. Whatever drugs causing serious damage of HVEC may contribute to the therapy for cavernous hemagiomas.

Key words: sclerosing agent, experimental model, cavernous hemagioma