Hydrogen peroxide and compound chlorhexidine gargle induced anaphylactic shock: a case report and literature review

doi:10.7518/hxkq.2025.2024324

Abstract

Abstract:

Severe allergic reactions to hydrogen peroxide solution and compound chlorhexidine gargle are rare, and most medical professionals have limited understanding of such cases. This article reports a case of anaphylactic shock in a patient with a periodontal abscess following oral flushing with hydrogen peroxide and compound chlorhexidine gargle. Drawing on domestic and international literature, it provides a reference for the emergency management of serious adverse reactions caused by these agents.

Key words: hydrogen peroxide solution, compound chlorhexidine gargle, anaphylaxis, adverse drug reaction

CLC Number:

R988.2

Zhong Siyu, Yu Zhujun, Ma Beibei, Li Dandan, Wang Jianli. Hydrogen peroxide and compound chlorhexidine gargle induced anaphylactic shock: a case report and literature review[J]. West China Journal of Stomatology, 2025, 43(3): 436-441.

Figures/Tables 2

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病例	性别	年龄/岁	用药原因	过敏史	浓度	不良反应	结局	参考文献
1	男	/	中指刺伤	青霉素	3%	过敏性休克	好转	[9]
2	女	41	腹部疖肿感染	/	3%	过敏性休克	好转	[10]
3	男	42	牙槽脓肿	青霉素	3%	过敏性休克	好转	[11]
4	男	23	拇指受伤	无	3%	过敏性休克	好转	[12]
5	男	64	化脓性胆管炎	/	3%	心跳呼吸骤停	好转	[13]
6	男	70	双肾积水	/	3%	心跳呼吸骤停	好转	[13]
7	男	61	胆管炎	/	3%	心跳呼吸骤停	好转	[13]
8	男	53	肾结石	/	3%	心跳呼吸骤停	好转	[13]
9	男	64	胆管结石	/	/	心跳呼吸骤停	好转	[14]
10	男	32	颅脑缺损	/	/	肺动脉气体栓塞	好转	[15]

病例	性别	年龄/岁	接触源	用药原因	过敏史	浓度	不良反应	结局	参考文献
1	/	20	凝胶	预防新冠病毒	/	0.05%	荨麻疹	好转	[16]
2	男	87	溶液、凝胶	膀胱镜检查	无	0.5%，0.05%	过敏性休克	好转	[17]
3	男	51	溶液、凝胶	膀胱切除术	无	0.5%，0.05%	过敏性休克	好转	[17]
4	男	69	消毒液	检查既往手术过敏原因	青霉素	/	过敏性休克	好转	[17]
5	男	61	消毒液	半结肠切除术	动物毛皮、花粉	0.5%	过敏性休克	好转	[17]
6	男	79	消毒液	胆囊切除术	/	1%	皮疹	好转	[18]
7	男	89	消毒液	腹股沟疝气成形术	/	0.5%	皮疹、低血压	好转	[18]
8	男	9	消毒液	右侧角膜白斑治疗手术	/	0.5%	过敏性休克	好转	[19]
9	男	26	消毒液	包皮环切术	/	1%	过敏性休克	好转	[19]
10	女	31	消毒液	宫颈锥形切除术	/	0.5%	过敏性休克	好转	[19]
11	男	48	消毒液	鼻下动脉粥样硬化斑块切除术	/	0.5%	眼睑荨麻疹	好转	[19]
12	男	15	消毒液	额头伤口消毒	/	0.5%	过敏性休克	好转	[19]
13	男	9	消毒液	上唇伤口消毒	/	0.05%	全身荨麻疹	好转	[19]
14	男	36	消毒液	结直肠切除术	/	2%	低血压	好转	[20]
15	男	16	消毒液	急性淋巴细胞白血病化疗插管	无	2%	过敏性休克	好转	[21]
16	男	58	牙膏	上颌牙龈红斑活检术	无	0.004%	灼烧感	好转	[22]
17	女	69	含漱液	漱口	无	0.2%	荨麻疹	好转	[23]
18	女	65	含漱液	未提及	/	/	口腔炎	好转	[24]
19	女	65	含漱液	未提及	/	/	口腔炎	好转	[24]
20	女	21	含漱液	口腔溃疡漱口	克林霉素	/	过敏性休克	好转	[25]
21	女	77	含漱液	冲洗牙龈脓肿	阿莫西林、头孢类	/	过敏性休克	死亡	[26]
22	男	63	含漱液	拔牙后冲洗牙槽	/	/	过敏性休克	死亡	[27]
23	女	30	含漱液	拔牙后冲洗牙槽	/	/	过敏性休克	死亡	[27]