West China Journal of Stomatology ›› 2017, Vol. 35 ›› Issue (6): 629-635.doi: 10.7518/hxkq.2017.06.013

• Orginal Article • Previous Articles     Next Articles

Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review

Xiaotong Wang(), Nanquan Rao, Jing Xie, Yuming Zhao, Lihong Ge()   

  1. Dept. of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
  • Received:2017-01-17 Revised:2017-09-08 Online:2017-12-20 Published:2017-12-01


Objective This study aims to assess the remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by performing system review of randomized controlled trials (RCT) involving the treatment of enamel demineralization with CPP-ACP. Methods The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up to September 2016. RCT of treating enamel demineralization with CPP-ACP were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers. Results Twelve RCTs were included. Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out. Conclusion There is no strong evidence that CPP-ACP is superior to con-ventional fluoride formulations in enamel remineralization. However, due to the limitations of sample size, follow-up time and study design, more high quality and large-sample RCT are needed to further verify the evidence.

Key words: casein phosphopeptide-amorphous calcium phosphate, randomized controlled trial, system review, white spot lesion

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