West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (5): 493-500.doi: 10.7518/hxkq.2021.05.001


Targeting-YAP/TAZ therapies for head and neck cancer, directly or indirectly?

Feng Xiaodong.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-11-24 Revised:2021-07-17 Online:2021-10-01 Published:2021-10-11
  • Contact: Feng Xiaodong. E-mail:xiaodongfeng@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(81672677);The Fundamental Research Funds for the Central Universities(YJ201987);The Scientific Research Foundation for Recruited Talents-West China Hospital of Stomatology, Sichuan University(QDJF2019-3);Correspondence: Feng Xiaodong, E-mail: xiaodongfeng@scu.edu.cn


YAP/TAZ are wild over-activated in head and neck squamous cell carcinoma (HNSCC) with high potential as a direct therapy target for HNSCC treatments. However, the efforts on the directly targeting-YAP/TAZ therapies over the past decade, have very limited impacts, mainly caused by: 1. There is still none effective and specific YAP/TAZ inhibitor with clinical potential; 2. YAP/TAZ might not be directly targeted, because of their multiple important biological functions, such as: regulation of cell proliferation and survival, stem cell maintain, regulation of organ development, organ size control, and tissue regeneration. Interestingly, the over-activation of YAP/TAZ in HNSCC mainly be regulated by upstream abnormal molecular or biological events, instead of genes alteration of YAP/TAZ. Therefore, exploring the alternative molecular events regulating YAP/TAZ activation and molecular mechanism in HNSCC might help to uncover novel indirect targets of YAP/TAZ therapies for HNSCC prevention and treatment.

Key words: YAP, TAZ, Hippo, head and neck cancer, targeting therapies

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