The prognostic value of preoperative peripheral blood inflammatory indicators for squamous cell carcinoma of tongue

doi:10.7518/hxkq.2022.03.014

Abstract

Abstract: Objective

A study was conducted to investigate the value of preoperative peripheral blood inflammatory indicators in the prediction of tongue squamous cell carcinoma (TSCC) prognosis.

Methods

This retrospective analysis included 210 patients who underwent radical resection for TSCC in the Department of Oral and Maxillofacial Surgery of The First Affiliated Hospital of Zhengzhou University from January 2010 to December 2017. Receiver operating characteristic curve was conducted to determine the best cut-off values of platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR). The Kaplan-Meier method and Log-rank test were conducted for univariate analysis, and the Cox proportional hazard regression model was conducted for multivariate analysis. A Nomogram model was established based on the independent risk factors, which were screened by Cox regression model.

Results

The univariate analysis showed that PLR, NLR, tumor differentiation, and T, N, and TNM stages were TSCC’s prognostic factors (P<0.05). Multivariate analysis showed that PLR and N and TNM stages were TSCC's independent risk factors (P<0.05). The C-index of the Nomogram was 0.701 (95%CI: 0.651-0.752). The calibration curve shows that the predicted survival rate of the nomogram was in good agreement with the relative survival rate.

Conclusion

Preoperative peripheral blood inflammatory indicators can potentially be used to predict TSCC prognosis.

Key words: peripheral blood inflammatory indicators, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, tongue squamous cell carcinoma, prognosis, Nomogram model

CLC Number:

R 782

Qin Shuo, Li Chunmei, Li Ran, Hu Shuang, Li Guanghui, Sun Minglei. The prognostic value of preoperative peripheral blood inflammatory indicators for squamous cell carcinoma of tongue[J]. West China Journal of Stomatology, 2022, 40(3): 335-340.

Figures/Tables 7

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影响因素	例数（%）	生存时间/月（均数±标准差）	P值
性别			0.996
女	78（37.14）	41.31±25.57
男	132（62.86）	41.10±23.57
年龄/岁			0.461
≤55	138（65.71）	41.94±24.69
>55	72（34.29）	39.69±23.54
PLR			<0.000 1
≤155.67	156（74.29）	47.22±23.25
>155.67	54（25.71）	23.70±18.15
NLR			0.000 2
≤2.13	131（62.38）	46.24±24.88
>2.13	79（37.62）	32.77±20.84
肿瘤部位			0.152
舌前2/3	163（77.62）	32.33±2.78
舌根	47（22.38）	24.84±3.42
切除范围			0.177
半舌	152（72.38）	28.60±2.15
局部	58（27.62）	30.12±4.98
分化程度			0.035
高分化	92（43.81）	43.78±3.28
中、低分化	118（56.19）	16.34±1.34
T分期			0.016
T1	93（44.29）	36.85±3.73
T2、T3	117（55.71）	23.87±2.30
N分期			0.004
N0	122（58.10）	37.68±3.06
N1、N2	88（41.90）	15.92±1.67
TNM分期			0.001
Ⅰ、Ⅱ	120（57.14）	39.95±2.97
Ⅲ、Ⅳ	90（42.86）	14.75±1.80

影响因素	风险比（95%CI）	P值
PLR（>155.67/≤155.67）	2.465（2.090~5.396）	<0.000 1
NLR（>2.13/≤2.13）	1.537（0.954~2.475）	0.077
分化程度（高、中/低）	0.459（0.536~1.376）	0.527
T分期（T1、T2/T3）	0.869（0.418~1.062）	0.088
N分期（N0、N1/N2）	1.226（1.153~6.087）	0.022
TNM分期（Ⅲ+Ⅳ期/Ⅰ+Ⅱ期）	3.596（1.398~3.547）	0.001

影响因素	PLR>155.67组	PLR≤155.67组	χ²值	P值
性别			0.925	0.336
男	31（57.41）	101（64.74）
女	23（42.59）	55（35.26）
年龄/岁			0.026	0.872
≤55	35（64.81）	103（66.03）
>55	19（35.19）	53（33.97）
肿瘤部位			1.219	0.269
舌前2/3	35（64.81）	124（79.49）
舌根	19（35.19）	32（20.51）
切除范围			2.082	0.149
半舌	35（64.81）	117（75）
局部	19（35.19）	39（25）
分化程度			0.556	0.456
高分化	26（48.15）	66（42.31）
中、低分化	28（51.85）	90（57.69）
T分期			0.119	0.730
T1	25（46.29）	68（43.59）
T2、T3	29（53.71）	88（56.41）
N分期			0.104	0.747
N0	30（55.56）	92（58.97）
N1、N2	24（44.44）	64（41.03）
TNM分期			0.351	0.554
Ⅰ、Ⅱ	29（53.71）	91（58.33）
Ⅲ、Ⅳ	25（46.29）	65（41.67）

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